Evaluation of Drug Candidates for Preclinical Development 1st Edition by Chao Han, Charles B Davis, Binghe Wang ISBN 0470044918 9780470044919

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Product details:

ISBN 10: 0470044918

ISBN 13: 9780470044919 

Author: Chao Han, Charles B. Davis, Binghe Wang

Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation

It is believed that selecting the “right” drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development.

Encompassing the three major interrelated areas in which optimization and evaluation of drug developability is most critical pharmacokinetics and drug metabolism, pharmaceutics, and safety assessment this unique resource encourages integrated thinking in drug discovery. The contributors to this volume:

• Cover drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, stability, drug formulation, preclinical safety assessment, toxicology, and toxicokinetics

• Address developability issues that challenge pharma companies, moving beyond isolated experimental results

• Reveal connections between the key scientific areas that are critical for successful drug discovery and development

• Inspire forward-thinking strategies and decision-making processes in preclinical evaluation to maximize the potential of drug candidates to progress through development efficiently and meet the increasing demands of the marketplace

Evaluation of Drug Candidates for Preclinical Development serves as an introductory reference for those new to the pharmaceutical industry and drug discovery in particular. It is especially well suited for scientists and management teams in small- to mid-sized pharmaceutical companies, as well as academic researchers and graduate students concerned with the practical aspects related to the evaluation of drug developability.

Table of contents:

1. Introduction
2. Pharmacokinetics in Preclinical Drug Development: An Overview
3. The Role of Membrane Transporters in Drug Disposition
4. Cytochrome P450: Structure, Function, and Application in Drug Discovery and Development
5. The Role of Drug Metabolism and Metabolite Identification in Drug Discovery
6. Protein Binding in Drug Discovery and Development
7. Prediction of the Pharmacokinetics in Humans
8. Pharmaceutics Developability Assessment
9. Safety Assessment in Drug Discovery
10. Assessment of Strategies Utilized to Minimize the Potential for Induction of Acquired Long QT Syndrome and Torsade DE Pointes

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Tags: Chao Han, Charles B Davis, Binghe Wang, Evaluation, Drug Candidates, Preclinical Development