Phase I Cancer Clinical Trials A Practical Guide 2nd Edition by Elizabeth A Eisenhauer, Christopher Twelves, Marc Buyse ISBN 0199359016 9780199359011

Phase I Cancer Clinical Trials A Practical Guide 2nd Edition by Elizabeth A. Eisenhauer, Christopher Twelves, Marc Buyse – Ebook PDF Instant Download/Delivery: 0199359016, 9780199359011

Full download Phase I Cancer Clinical Trials A Practical Guide 2nd Edition after payment

Product details:

ISBN 10: 0199359016

ISBN 13: 9780199359011 

Author: Elizabeth A. Eisenhauer, Christopher Twelves, Marc Buyse

Phase I trials are a critical first step in the study of novel cancer therapeutic approaches. Their primary goals are to identify the recommended dose, schedule and pharmacologic behavior of new agents or new combinations of agents and to describe the adverse effects of treatment. In cancer therapeutics, such studies have particular challenges. Due to the nature of the effects of treatment, most such studies are conducted in patients with advanced malignancy, rather than in healthy volunteers. Further, the endpoints of these trials are usually measures adverse effects rather than molecular target or anti-tumor effects. These factors render the design, conduct, analysis and ethical aspects of phase I cancer trials unique. As the only comprehensive book on this topic, Phase I Cancer Clinical Trials is a useful resource for oncology trainees or specialists interested in understanding cancer drug development. New to this edition are chapters on Phase 0 Trials and Immunotherapeutics, and updated information on the process, pitfalls, and logistics of Phase I Trials

Table of contents:

1. Introduction
2. Preclinical Data and Requirements
3. Phase 0 Clinical Trials
4. Basics of Phase I Design: First-in-man Studies
5. Ethical Issues in First-in-human Phase I Cancer Trials
6. Phase I Trials in Special Populations and Circumstances
7. Phase I Trials of Immunotherapeutics
8. Statistical Designs for First-in-human Phase I Trials
9. Writing the Protocol
10. Practical Aspects of Pharmacokinetics and Pharmacodynamics
11. Process, Pitfalls, and Logistics of Phase I Trials
12. Reporting and Interpreting Results

People also search for:

phase i cancer clinical trials a practical guide
    
phase 1 cancer clinical trials
    
phases of cancer clinical trials
    
phase i trials in oncology
    
phase 1 cancer clinical trials a practical guide

Tags: Elizabeth A Eisenhauer, Christopher Twelves, Marc Buyse, Phase I, Cancer Clinical Trials, Practical Guide