Annual Reports in Medicinal Chemistry Volume 39 1st Edition by Annette Doherty ISBN 0120405393 9780120405398

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Product details:

ISBN 10: 0120405393

ISBN 13: 978-0120405398

Author: Annette M. Doherty 

Annual Reports in Medicinal Chemistry (Volume 39) 1st Edition: 

Annual Reports in Medicinal Chemistry continues to focus on providing timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

Sections I-IV are disease orientated and generally report on specific medicinal agents.

Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design.

 

Annual Reports in Medicinal Chemistry (Volume 39) 1st Edition Table of contents:

I. Central nervous system diseases

• Attention deficit hyperactivity disorder: Pathophysiology and design of new treatments
• Ionotropic GABA receptors as therapeutic targets for memory and sleep disorders
• Melatonin agonists for the treatment of sleep disorders and major depression

II. Cardiovascular and metabolic diseases

• Recent advances in therapeutic approaches to type 2 diabetes
• Recent progress in histamine H3 receptor chemistry
• Anti-resorptive and anabolic bone agents
• Inhibition of the cysteine protease cathepsin-K
• Nonpeptide gonadotropin releasing hormone antagonists

III. Inflammatory, pulmonary, and gastrointestinal diseases

• Bradykinin B2 antagonists for the treatment of pain
• Selective cyclooxygenase-2 inhibitors
• The discovery of small molecule C5a antagonists
• CCR1 antagonists

IV. Cancer and infectious diseases

• Recent advances in antimetabolite cancer chemotherapies
• Mitotic kinesin inhibitors as novel anticancer agents
• Recent advances in medicinal chemistry of histone deacetylase inhibitors
• Therapeutic opportunities for the treatment of biofilm-associated infections
• Biowarfare pathogens: Is the research flavor different than that of clinically relevant pathogens?
• HCV antiviral agents

V. Topics in biology

• Pleiotropic effects of statins
• Comparative protein structure modeling and its applications to drug discovery

VI. Topics in drug design and discovery

• Drug transporters and their role in tissue distribution
• The hit-to-lead process in drug discovery
• Prodrug strategies in the design of nucleoside and nucleotide antiviral therapeutics
• Pre-clinical assessment of drug-induced QT interval prolongation: Current issues and impact on drug discovery

VII. Trends and perspectives

• To market, to market—2003

 

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