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Biochips As Pathways To Drug Discovery Drug Discovery Series 1st Edition by Andrew Carmen,Gary Hardiman ISBN 1574444506 978-1574444506

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Biochips As Pathways To Drug Discovery Drug Discovery Series 1st Edition Andrew Carmen (Editor) Digital Instant Download

Author(s): Andrew Carmen (Editor), Gary Hardiman (Editor)
ISBN(s): 9781574444506, 1574444506
Edition: 1
File Details: PDF, 14.29 MB
Year: 2006
Language: english
SKU: EB-2164176 Category: Tags: ,

Biochips As Pathways To Drug Discovery Drug Discovery Series 1st Edition by Andrew Carmen, Gary Hardiman – Ebook PDF Instant Download/Delivery: 1574444506, 978-1574444506

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Product details:

ISBN 10: 1574444506

ISBN 13: 978-1574444506

Author: Andrew Carmen, Gary Hardiman

In the fiercely competitive pharmaceutical marketplace, your organization cannot afford to spend excess dollars developing drugs that will fail to get FDA approval or have profoundly poor characteristics. Biochips as Pathways to Drug Discovery takes a comprehensive look at how the industry faces these challenges, using new technologies such as biochips to reduce the cost of drug discovery and improve drug safety. The book explores the tools and skills required at each step of the discovery process when using biochips to determine biological outcomes.

The authors provide an in-depth review of the clinical and pharmacogenomic relevance of biochips, ChIP-chip assays, and high-throughput approaches. They discuss how biochips are used to develop biomarkers in the drug discovery process, primarily for gene expression profiling and Single Nucleotide Polymorphism (SNP) analysis. The book includes coverage of experimental theory, quality control, clinical laboratory sampling considerations, database concepts, industrial laboratory design, and the analysis of the resultant large data sets. It discusses the application of biochips to the study of malaria, toxicogenomics, and SNPs, as well as intellectual property and market overviews. The book concludes with a comprehensive overview of how these chips are employed from early target discovery through preclinical toxicology and on through to pharmacogenomic and proof of concept studies in humans.

Written in an easily accessible style, the breadth of coverage introduces the subject to those new to the field, while the depth of coverage forms a foundation for future work. The book gives you the knowledge required to leverage the technology into bona fide discoveries.

Table of contents:

  1. DNA Biochips — Past, Present, and Future: An Overview

  2. Three-Dimensional HydroArrays: Novel Microarrays for Genomic and Proteomic Studies

  3. Biochip in Malaria for Antiparasitic Discovery

  4. Regional Variations in Intestinal ATP-Binding Cassette Transporter Expression Identified with a Global Error Assessment Model

  5. Toxicogenomics in Drug Safety Evaluation: Bridging Drug Discovery and Development

  6. The Next Generation of Automated Microarray Platforms for a Multiplexed CYP2D6 Assay

  7. Biopsy and RNA Extraction Procedures of Muscle and Adipose Tissue for Microarray Gene-Expression Profiling

  8. ChIP-on-Chip: Analysis of Genomewide Protein Binding and Posttranslational Modifications

  9. DNA Microarrays as Functional Genomics Tools for Cancer Drug Discovery

  10. High-Throughput Microarray Analysis

  11. Laboratory Automation: Strategies for High-Volume Industrial Microarray Programs

  12. Association Studies: Practical and Theoretical Considerations for Drug Discovery, Evaluation, and Beyond

  13. Approaches for Microarray Data Validation

  14. Microarray Enterprise Information Management: What Is It and Why Is It Important?

  15. Quality Control of Microarray Data

  16. Microarray Data Normalization and Transformation

  17. Amplification Strategies and DNA Biochips

  18. Ribo-SPIA™, a Rapid Isothermal RNA Amplification Method for Gene Expression Analysis

  19. Genomics, Transcriptomics, and Proteomics: Novel Detection Technologies and Drug Discovery

  20. Intellectual Property Issues for DNA Chips and Microarrays

  21. Biochips: Market Drivers and Commercial Prospect

  22. A Pharmaceutical Perspective for Microarrays and Biochips: Current-Market Overview and Future Trends

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