Burger’s Medicinal Chemistry and Drug Discovery Volume 1 6th Edition by Donald J Abraham ISBN 0471370320 978-0471370321

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Product details:

ISBN 10: 0471370320 

ISBN 13: 978-0471370321

Author: Donald J. Abraham

This new sixth edition of Burger’s Medicinal Chemistry and Drug Discovery offers several new and unique features. For the first time, an online version of this major reference work will offer updated content from the print edition and easy access. For the first time, all volumes are structured entirely according to content and published simultaneously to provide broad coverage of medicinal chemistry and drug discovery for new or experienced medicinal chemists, biologists, pharmacologists and molecular biologists. This includes a current and global perspective of drug design, and drug development.

With expanded content from 69 chapters to over 100 chapters, this sixth edition of Burger’s Medicinal Chemistry and Drug Discovery includes more than 50% new material. An entire section has been dedicated to cancer research. Areas included are those at the foreground of life science including:
* Proteomics
* Genomics
* Bioinformatics
* Combinatorial Chemistry
* High-Throughput Screening
* Blood Substitutes
* Allosteric Effectors as Potential Drugs
* COX Inhibitors
* Statins
* High-Throughput Pharmacology
* and More.

The new sixth edition of Burger’s Medicinal Chemistry and Drug Discovery is a Memorial Edition to Professor Alfred Burger who published this major reference work in the first edition as “Medicinal Chemistry” in two volumes in 1951. Dr. Burger’s research focused on analgesics, antidepressants and chemotherapeutic agents. He is one of the few academicians to have a drug, designed and synthesized in his laboratories and brought to market. Dr. Burger’s contribution to the fields of medicinal chemistry and drug discovery are well renowned and documented. He received the Louis Pasteur Medal of the Pasteur Institute and the American Chemical Society Smissman Award.

Table of contents:

1. History of Quantitative Structure-Activity Relationships

2. Recent Trends in Quantitative Structure-Activity Relationships

3. Molecular Modeling in Drug Design

4. Drug-Target Binding Forces: Advances in Force Field Approaches

5. Combinatorial Library Design, Molecular Similarity, and Diversity Applications

6. Virtual Screening

7. Docking and Scoring Functions/Virtual Screening

8. Bioinformatics: Its Role in Drug Discovery

9. Chemical Information Computing Systems in Drug Discovery

10. Structure-Based Drug Design

11. X-Ray Crystallography in Drug Discovery

12. NMR and Drug Discovery

13. Mass Spectrometry and Drug Discovery

14. Electron Cryomicroscopy of Biological Macromolecules

15. Peptidomimetics for Drug Design

16. Analog Design

17. Approaches to the Rational Design of Enzyme Inhibitors

18. Chirality and Biological Activity

19. Structural Concepts in the Prediction of the Toxicity of Therapeutical Agents

20. Natural Products as Leads for New Pharmaceuticals

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