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Carbonic Anhydrase Its Inhibitors and Activators 1st Edition by Claudiu T Supuran, Andrea Scozzafava,Janet Conway ISBN 0415306736 978-0415306737

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Carbonic Anhydrase Its Inhibitors and Activators 1st Edition Claudiu T. Supuran Digital Instant Download

Author(s): Claudiu T. Supuran, Andrea Scozzafava, Janet Conway
ISBN(s): 9780415306737, 0415306736
Edition: 1
File Details: PDF, 8.60 MB
Year: 2004
Language: english
SKU: EB-1619502 Category: Tags: , ,

Carbonic Anhydrase Its Inhibitors and Activators 1st Edition by Claudiu T Supuran, Andrea Scozzafava,Janet Conway – Ebook PDF Instant Download/Delivery: 0415306736,978-0415306737
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Product details: 

ISBN 10: 0415306736 

ISBN 13: 978-0415306737

Author: Claudiu T Supuran, Andrea Scozzafava,Janet Conway

Carbonic Anhydrase: Its Inhibitors and Activators provides a state-of-the-art overview of the latest developments and challenges in carbonic anhydrase research. Authors describe the mechanisms of action of specific inhibitors in relation to physiological function, and present previously unpublished research on CA activators. Written by a team of internationally recognized experts, this authoritative edition is a leading reference for bioscientists across many disciplines, as well as novices interested in the latest developments in this complex field. An understanding of the mechanisms through which carbonic anhydrases interact with their inhibitors and activators in complex biological environments i

Table of contents: 

 

  1. COVER PAGE
  2. TITLE PAGE
  3. COPYRIGHT PAGE
  4. PREFACE
  5. CONTRIBUTORS
  6. 1: CARBONIC ANHYDRASES: CATALYTIC AND INHIBITION MECHANISMS, DISTRIBUTION AND PHYSIOLOGICAL ROLES
  7. 1.1 INTRODUCTION
  8. 1.2 CATALYTIC AND INHIBITION MECHANISMS OF CAs
  9. 1.3 DISTRIBUTION OF CAs
  10. 1.4 PHYSIOLOGICAL FUNCTIONS OF CAs
  11. REFERENCES
  12. 2: ACATALYTIC CAs: CARBONIC ANHYDRASE-RELATED PROTEINS
  13. 2.1 INTRODUCTION
  14. 2.2 MOLECULAR PROPERTIES OF CA-RPs
  15. 2.3 EVOLUTIONARY ANALYSIS AND SUBCELLULAR OCALIZATION OF CA-RPs
  16. 2.4 EXPRESSION OF CA-RPs
  17. 2.5 FUNCTIONAL PROSECUTION OF CA-RPs
  18. 2.6 FUTURE DIRECTION OF FUNCTIONAL ANALYSIS OF CA-RPs
  19. REFERENCES
  20. 3: MULTIPLE BINDING MODES OBSERVED IN X-RAY STRUCTURES OF CARBONIC ANHYDRASE INHIBITOR COMPLEXES AND OTHER SYSTEMS: CONSEQUENCES FOR STRUCTURE-BASED DRUG DESIGN JOCHEN ANTEL, ALEXANDER WEBER, CHRISTOPH A.
  21. 3.1 INTRODUCTION
  22. 3.2 BINDING OF SUGAR SULFAMATES TO CAs
  23. 3.3 CONCLUSIONS
  24. REFERENCES
  25. 4: DEVELOPMENT OF SULFONAMIDE CARBONIC ANHYDRASE INHIBITORS
  26. 4.1 INTRODUCTION
  27. 4.2 CLASSICAL INHIBITORS
  28. 4.3 TOPICAL SULFONAMIDES AS ANTIGLAUCOMA AGENTS
  29. 4.4 ISOZYME-SPECIFIC INHIBITORS
  30. 4.6 ANTITUMOR SULFONAMIDES
  31. 4.7 SULFONAMIDES WITH MODIFIED MOIETIES AND OTHER ZINC-BINDING GROUPS
  32. 4.8 ANTIEPILEPTIC SULFONAMIDES AND OTHER MISCELLANEOUS INHIBITORS
  33. 4.9 ALIPHATIC SULFONAMIDES
  34. 4.10 FUTURE PROSPECTS OF CAIs
  35. REFERENCES
  36. 5: QSAR STUDIES OF SULFONAMIDE CARBONIC ANHYDRASE INHIBITORS
  37. 5.1 INTRODUCTION
  38. 5.2 BENZENOID AROMATICS
  39. 5.3 HETEROAROMATICS
  40. 5.4 ALIPHATICS
  41. 5.5 CONCLUSIONS
  42. ACKNOWLEDGEMENTS
  43. REFERENCES
  44. 6: METAL COMPLEXES OF HETEROCYCLIC SULFONAMIDES AS CARBONIC ANHYDRASE INHIBITOR
  45. 6.1 INTRODUCTION
  46. 6.2 ACETAZOLAMIDE COMPLEXES
  47. 6.3 METHAZOLAMIDE COMPLEXES
  48. 6.5 COMPLEXES CONTAINING OTHER SULFONAMIDE CAIs
  49. 6.6 APPLICATIONS OF METAL COMPLEXES OF SULFONAMIDES IN THERAPY
  50. REFERENCES
  51. 7: NONSULFONAMIDE CARBONIC ANHYDRASE INHIBITORS
  52. 7.1 INTRODUCTION
  53. 7.2 INHIBITION OF CAS BY ANIONS
  54. 7.3 OTHER TYPES OF NONSULFONAMIDE INHIBITORS
  55. REFERENCES
  56. 8: CLINICAL APPLICATIONS OF CARBONIC ANHYDRASE INHIBITORS IN OPHTHALMOLOGY
  57. 8.1 INTRODUCTION
  58. 8.2 SULFONAMIDES IN THE TREATMENT OF GLAUCOMA
  59. 8.3 COMBINATION ANTIGLAUCOMA THERAPY OF CAIs WITH OTHER PHARMACOLOGICAL AGENTS
  60. 8.4 CAIs IN MACULAR EDEMA, MACULAR DEGENERATION AND RELATED OCULAR PATHOLOGIES
  61. REFERENCES
  62. 9: CANCER-RELATED CARBONIC ANHYDRASE ISOZYMES AND THEIR INHIBITION
  63. 9.1 INTRODUCTION
  64. 9.2 IDENTIFICATION, STRUCTURE AND DISTRIBUTION OF CA IX
  65. 9.3 REGULATION OF CA IX EXPRESSION
  66. 9.4 CA IX AS A MARKER OF TUMOR HYPOXIA
  67. 9.5 IDENTIFICATION, DISTRIBUTION AND REGULATION OF CA XII
  68. 9.6 CATALYTIC PROPERTIES AND PROPOSED ROLES OF CA IX AND CA XII
  69. 9.7 INFLUENCE OF EXTRACELLULAR PH ON TUMOR PROGRESSION AND POSSIBLE IMPLICATION OF CA ACTIVITY
  70. 9.8 CA INHIBITION AS AN APPROACH TO ANTICANCER THERAPY
  71. 9.9 INHIBITION PROFILE OF CA IX
  72. 9.10 CONCLUSIONS
  73. ACKNOWLEDGMENTS
  74. REFERENCES
  75. 10: ROLE OF CARBONIC ANHYDRASE AND ITS INHIBITORS IN GASTROENTEROLOGY, NEUROLOGY AND NEPHROLOGY
  76. 10.1 ROLE OF CAS IN THE ALIMENTARY TRACT
  77. 10.2 CAIs IN THE ALIMENTARY TRACT
  78. 10.3 ROLE OF CAS IN THE KIDNEY
  79. 10.4 CAIs IN THE KIDNEY
  80. 10.5 ROLE OF CAS IN THE NERVOUS SYSTEM
  81. 10.6 CAIs IN THE NERVOUS SYSTEM
  82. ACKNOWLEDGMENTS
  83. REFERENCES
  84. 11: CARBONIC ANHYDRASE INHIBITORS IN DERMATOLOGY
  85. 11.1 INTRODUCTION
  86. 11.2 CAS IN THE SKIN
  87. 11.3 ROLE OF CAS IN THE SKIN
  88. 11.4 ROLE OF CAS IN SKIN DISEASES
  89. 11.5 ROLE OF CAS IN SKIN TUMORS
  90. 11.6 CAIs AND SKIN CANCER
  91. REFERENCES
  92. 12: CARBONIC ANHYDRASE ACTIVATORS
  93. 12.1 INTRODUCTION
  94. 12.2 MECHANISM OF ACTION OF CAAS
  95. 12.3 CAAS TYPES: DESIGN STRATEGIES, STRUCTURE–ACTIVITY RELATIONSHIPS AND ISOZYME SPECIFICITY
  96. 12.4 CONNECTIONS OF CAAS WITH PHYSIOPATHOLOGY: POSSIBLE CLINICAL DEVELOPMENTS
  97. 12.5 CONCLUDING REMARKS
  98. REFERENCES

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