(EBOOK PDF) Chiral Amine Synthesis Methods Developments and Applications 1st Edition by Thomas Nugent ISBN 3527325093 9783527325092 full chapters

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Product details:

ISBN 10: 3527325093

ISBN 13: 978-3527325092

Author: Thomas C. Nugent 

Chiral Amine Synthesis: Methods, Developments and Applications 1st Edition: This first comprehensive presentation of this hot and important topic compiles the most up-to-date methods for chiral amine synthesis. The international list of authors reads like a “Who’s Who” of the subject, providing a large array of highly practical information concentrated into the useful and essential methods.
Following an introductory chapter devoted to helping readers quickly determine which strategies to choose for their investigation, this handbook and ready reference focuses on the examination of methods that are reliable and simultaneously efficient for the synthesis of structurally diverse aliphatic and aromatic chiral amines. Modern methods and applications found in (pharmaceutical) industry are also covered.

 

Chiral Amine Synthesis: Methods, Developments and Applications 1st Edition Table of contents:

• STEREOSELECTIVE SYNTHESIS OF ALPHA-BRANCHED AMINES BY NUCLEOPHILIC ADDITION OF UNSTABILIZED CARBANIONS TO IMINES

  • Introduction
  • Overview of the Methods for the Preparation of Imines
  • Chiral Auxiliary-Based Approaches
  • Catalytic Asymmetric Nucleophilic Addition to Achiral Imines
  • Conclusion

• ASYMMETRIC METHODS FOR RADICAL ADDITION TO IMINO COMPOUNDS

  • Background and Introduction
  • Intermolecular Radical Addition Chiral N-Acylhydrazones
  • Asymmetric Catalysis of Radical Addition
  • Closing Remarks

• ENANTIOSELECTIVE SYNTHESIS OF AMINES BY CHIRAL BRONSTED ACID CATALYSTS

  • Introduction
  • Carbon-Carbon Bond Forming Reactions
  • Carbon-Hydrogen Bond Forming Reactions
  • Carbon-Heteroatom Bond Forming Reactions
  • Conclusion

• REDUCTION OF IMINES WITH TRICHLOROSILANE CATALYZED BY CHIRAL LEWIS BASES

  • Introduction
  • Formamides as Lewis-Basic Organocatalysts in Hydrosilylation of Imines
  • Other Amides as Organocatalysts in Hydrosilylation of Imines
  • Sulfinamides as Organocatalysts in Hydrosilylation of Imines
  • Supported Organocatalysts in Hydrosilylation of Imines
  • Mechanistic Considerations
  • Synthetic Applications
  • Conclusions
  • Typical Procedures for the Catalytic Hydrosilylation of Imines

• CATALYTIC, ENANTIOSELECTIVE; VINYLOGOUS MANNICH REACTIONS

  • Introduction
  • Vinylogous Mukaiyama-Mannich Reactions of Silyl Dienolates
  • Direct Vinylogous Mannich Reactions of Unmodified Substrates
  • Miscellaneous
  • Conclusion

• CHIRAL AMINES FROM TRANSITION-METAL-MEDIATED HYDROGENATION AND TRANSFER HYDROGENATION

  • Scope and Related Publications
  • Chiral Amines with a Disubstituted Nitrogen Atom, HNR*R1
  • Chiral Amines with Trisubstituted Nitrogen, NR*R1R2
  • Conclusion

• ASYMMETRIC REDUCTIVE AMINATION

  • Introduction
  • Transition Metal-Mediated Homogenous Reductive Amination
  • Enantioselective Organocatalytic Reductive Amination
  • Diastereoselective Reductive Amination
  • Conclusions

• ENANTIOSELECTIVE HYDROGENATION OF ENAMINES WITH MONODENTATE PHOSPHORUS LIGANDS

  • Introduction
  • Asymmetric Hydrogenation of Enamides
  • Asymmetric Hydrogenation of N,N-Dialkyl Enamines
  • Conclusion and Outlook

• BIDENTATE LIGANDS FOR ENANTIOSELECTIVE ENAMIDE REDUCTION

  • Introduction
  • Catalytic Enantioselective Hydrogenation of Enamides
  • Conclusions

• ENANTIOSELECTIVE REDUCTION OF NITROGEN-BASED HETEROAROMATIC COMPOUNDS

  • Asymmetric Hydrogenation of Quinolines
  • Asymmetric Hydrogenation of Isoquinolines
  • Asymmetric Hydrogenation of Pyrroles
  • Asymmetric Hydrogenation of Quinoxalines
  • Asymmetric Hydrogenation of Pyridine Derivatives
  • Summary and Outlook

• ASYMMETRIC HYDROAMINATION

  • Introduction: Synthesis of Amines via Hydroamination
  • Hydroamination of Simple, Nonactivated Alkenes
  • Hydroamination of Dienes, Allenes, and Alkynes
  • Hydroamination with Enantiomerically Pure Amines
  • Synthesis of Chiral Amines via Tandem Hydroamination/Hydrosilylation
  • Conclusions
  • Experimental Section

• ENANTIOSELECTIVE C-H AMINATION

  • Introduction
  • Background
  • Racemic C-H Amination
  • Substrate-Controlled Chiral Amine Synthesis via C-H Amination
  • Enantioselective C-H Amination of Achiral Substrates
  • Conclusion

• CHIRAL AMINES DERIVED FROM ASYMMETRIC AZA-MORITA-BAYLIS-HILLMAN REACTION

  • Introduction
  • Recent Mechanistic Insights
  • Asymmetric Aza-MBH Reaction
  • Chiral Auxiliary-Induced Diastereoselective Aza-MBH Reaction
  • Chiral Tertiary Amine Catalysts
  • Chiral Phosphine Catalysts
  • Chiral Bifunctional N-Heterocyclic Carbenes
  • Chiral Ionic Liquids as Reaction Medium
  • Aza-MBH-Type Reaction to Obtain Chiral Amines
  • Strategies for the Removal of Protecting Groups
  • Selected Typical Experimental Procedures
  • Summary and Outlook

• BIOCATALYTIC ROUTES TO NONRACEMIC CHIRAL AMINES

  • Introduction
  • Kinetic Resolution of Racemic Amines
  • DKR and Deracemization of Amines
  • Asymmetric Synthesis of Amines Using Transaminases
  • Conclusions and Future Perspectives

 

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Thomas Nugent,Chiral Amine,Synthesis,Methods,Developments,Applications