CNS Cancer Models Markers Prognostic Factors Targets and Therapeutic Approaches 1st Edition by Erwin G Meir ISBN 1603275525 978-1603275521

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Product details:

ISBN 10: 1603275525

ISBN 13: 978-1603275521 

Author: Erwin G. Meir

Cancers of the central nervous system are among the most lethal of human neoplasms. They are recalcitrant to even intensive multimodality therapies that include surgery, radiotherapy, and chemotherapy. Moreover, especially in children, the consequences of these therapies can itself be devastating and involve serious cognitive and developmental disorders. It is small wonder that such cancers have come under the intense scrutiny of each of the subspecialties of clinical care and investigation as well as attracting some of the best basic research scientists. Their joint efforts are gradually peeling away the mysteries surrounding the genesis and progression of these tumors and inroads are being steadily made into understanding why they resist therapies. This makes it an especially opportune time to assemble some of the best investigators in the field to review the ‘‘state of the art’’ in the various arenas that comprise the assault on CNS tumors. The breadth of this effort by the clinical and basic neuro-oncology community is quite simply amazing. To a large extent, it evolves from the knowledge of the human genome and its regulation that has been hard won over the past two decades.

Table of contents:

Part I: Animal Models for Central Nervous Tumors

1 Modeling Gliomas Using PDGF-Expressing Retroviruses
2 Modeling Brain Tumors Using Avian Retroviral Gene Transfer
3 Using Neurofibromatosis Type 1 Mouse Models to Understand Human Pediatric Low-Grade Gliomas
4 Transgenic Mouse Models of CNS Tumors: Using Genetically Engineered Murine Models to Study the Role of p21-Ras in Glioblastoma Multiforme
5 Pten-Deficient Mouse Models for High-Grade Astrocytomas
6 The Nfl-1+; Trp53-/+cis Mouse Model of Anaplastic Astrocytoma and Secondary Glioblastoma: Dissecting Genetic Susceptibility to Brain Cancer
8 Modeling Astrocytomas in a Family of Inducible Genetically Engineered Mice: Implications for Preclinical Cancer Drug Development
9 Human Brain Tumor Cell and Tumor Tissue Transplantation Models
10 Transformed Human Brain Cells in Culture as a Model for Brain Tumors
11 Rat Glioma Models for Preclinical Evaluation of Novel Therapeutic and Diagnostic Modalities
12 Neuro-oncogenesis Induced by Nitroso Compounds in Rodents and Strain-Specific Genetic Modifiers of Predisposition
13 The Murine GL261 Glioma Experimental Model to Assess Novel Brain Tumor Treatments
14 Spontaneous Occurrence of Brain Tumors in Animals: Opportunities as Preclinical Model Systems

Part II: Prognostic Factors and Biomarkers
14. p53 Pathway Alterations in Brain Tumors
15. The PTEN/PI3 Kinase Pathway in Human Glioma
16. Value of 1p/19q and Other LOH Markers for Brain Tumor Diagnosis, Prognosis, and Therapy
17. Discovery of Genetic Markers for Brain Tumors by Comparative Genomic Hybridization
18. Genomic Identification of Significant Targets in Brain Cancer
19. Oncomodulatory Role of the Human Cytomegalovirus
20. Aberrant EGFR Signaling in Glioma
21. Mechanisms of Brain Tumor Angiogenesis
22. Vaso-occlusive Mechanisms that Initiate Hypoxia and Necrosis in Glioblastoma: The Role of Thrombosis and Tissue Factor
23. Transcription Profiling of Brain Tumors: Tumor Biology and Treatment Stratification
24. Proteomic Profiling of Human Brain Tumors
25. Proteomic Discovery of Biomarkers in the Cerebrospinal Fluid of Brain Tumor Patients
26. Epigenetic Profiling of Gliomas
27. MicroRNAs in the Central Nervous System and Potential Roles of RNA Interference in Brain Tumors
28. Of Escherichia coli and Man: Understanding Glioma Resistance to Temozolomide Therapy
29. Brain Tumor Stem Cell Markers

Part III: Therapeutic Targets and Targeting Approaches
30. Clinical Agents for the Targeting of Brain Tumor Vasculature
31. Bone Marrow-Derived Cells in GBM Neovascularization
32. Vascular Targeting of Brain Tumors – Bridging the Gap with Phage Display
33. Impact of the Blood-Brain Barrier on Brain Tumor Imaging and Therapy
34. Targeting CXCR4 in Brain Tumors
35. Molecular Targeting of IL-13Rα2 and EphA2 Receptor in GBM
36. Molecular Targets for Antibody-Mediated Immunotherapy of Malignant Glioma
37. Stat3 Oncogenic Signaling in Glioblastoma Multiforme
38. Inhibition of Ras Signaling for Brain Tumor Therapy
39. HGF/c-Met Signaling and Targeted Therapeutics in Brain Tumors
40. Combinatorial Therapeutic Strategies for Blocking Kinase Pathways in Brain Tumors
41. Targeting of TRAIL Apoptotic Pathways for Glioblastoma Therapies
42. The NF-κB Signaling Pathway in GBMs: Implications for Apoptotic and Inflammatory Responses and Exploitation for Therapy
43. Targeting Endoplasmic Reticulum Stress for Malignant Glioma

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Tags: Erwin G Meir, CNS Cancer, Models, Markers, Prognostic Factors, Targets, Therapeutic Approaches