Developmental Origins of Health and Disease 1st Edition by Peter Gluckman,Mark Hanso ISBN 051116906X 9780521847438

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Product details:

ISBN 10: 051116906X

ISBN 13: 9780521847438

Author: Peter Gluckman, Mark Hanson 

This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis has begun to be studied in depth and fully understood. The compilation, written by many of the world’s leading experts in this exciting field, summarizes these scientific and clinical advances.

• Links early development to the onset of many chronic diseases such as coronary heart disease, diabetes and osteoporosis
• Explains concepts, possible mechanisms, outcomes and public health consequences
• A definitive account of a rapidly emerging area
• Authors of the The Fetal Matrix: Evolution, Development and Disease

Table of contents:

1. The developmental origins of health and disease: an overview
2. The ‘developmental origins’ hypothesis: epidemiology
3. The conceptual basis for the developmental origins of health and disease
4. The periconceptional and embryonic period
5. Epigenetic mechanisms
6. A mitochondrial component of developmental programming
7. Role of exposure to environmental chemicals in developmental origins of health and disease
8. Maternal nutrition and fetal growth and development
9. Placental mechanisms and developmental origins of health and disease
10. Control of fetal metabolism: relevance to developmental origins of health and disease
11. Lipid metabolism: relevance to developmental origins of health and disease
12. Prenatal hypoxia: relevance to developmental origins of health and disease
13. The fetal hypothalamic-pituitary-adrenal axis: relevance to developmental origins of health and disease
14. Perinatal influences on the endocrine and metabolic axes during childhood
15. Developmental origins of health and disease: relevance of patterns of growth
16. The developmental environment and the endocrine pancreas
17. The develop
28. The developmental environment and the origins of neurological disorders mental environment and insulin resistance
18. The developmental environment and the development of obesity
19. The developmental environment and its role in the metabolic syndrome
20. Programming the cardiovascular system
21. The role of vascular dysfunction in developmental
22. The developmental environment and atherogenesis origins of health and disease: evidence from studies in man and animals
23. The developmental environment, renal function and disease
24. The developmental environment: effect on fluid and electrolyte homeostasis
25. The developmental environment: effects on lung structure and function
26. Developmental origins of asthma and related allergic disorders
27. The developmental environment: Influences on subsequent cognitive function and behaviour
28. The developmental environment and the origins of neurological disorders
29. The developmental environment: clinical perspectives on effects on the musculoskeletal system
30. The developmental environment: experimental perspectives on skeletal development
31. The developmental environment and the early origins of cancer
32. The developmental environment: implications for aging and lifespan
33. Developmental origins of health and disease: implications for primary intervention for cardiovascular and metabolic disease
34. Developmental origins of health and disease: public health perspectives
35. Developmental origins of health and disease: implications for developing countries
36. Developmental origins of health and disease: ethical and social considerations.

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Tags: Peter Gluckman, Mark Hanso, Developmental Origins, Health, Disease