Drug Transporters Molecular Characterization and Role in Drug Disposition 1st Edition by Guofeng You, Marilyn E Morris, Binghe Wang ISBN 0471784915 9780471784913
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Product details:
ISBN 10: 0471784915
ISBN 13: 9780471784913
Author: Guofeng You, Marilyn E. Morris, Binghe Wang
A comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body
The development of powerful expression cloning and genome analysis techniques has facilitated the molecular identification and characterization of numerous transporters that play a crucial role in drug disposition. Explaining the principles of drug transport and the associated techniques, Drug Transporters: Molecular Characterization and Role in Drug Disposition:
*Provides a comprehensive overview of drug transporters
*Includes specific descriptions of transporter families, including substrate and inhibitor specificity, subcellular and tissue localization, mechanisms governing transport, species differences, the clinical implications of these transporters in human physiology and disease, and their role in drug distribution, elimination, and interactions in drug therapy
*Describes transporter-mediated drug disposition, a newly emerging field in drug therapy
*Gives a comprehensive summary of drug transport across biological membranes
*in the liver, brain, kidney, and intestine
*Provides balanced coverage of mechanistic aspects and functional outcomes
*Features chapters contributed by distinguished scientists in their specialty areas
*Provides sufficient detail to enable non-specialists to understand the principles and techniques
This authoritative guide is a practical hands-on desk reference for researchers in academia and the pharmaceutical industry and scientists in government agencies. It is also an excellent text for graduate-level courses in the pharmaceutical and pharmacology fields.
Table of contents:
Frontmatter
Color Plates
CHAPTER 1: Overview of Drug Transporter Families
CHAPTER 2: Organic Cation Transporters
CHAPTER 3: Organic Cation/Carnitine Transporters
CHAPTER 4: Organic Anion Transporters
CHAPTER 5: Organic Anion–Transporting Polypeptides
CHAPTER 6: Mammalian Oligopeptide Transporters
CHAPTER 7: Monocarboxylate Transporters
CHAPTER 8: Nucleoside Transporters: CNTs and ENTs
CHAPTER 9: Bile Acid Transporters
CHAPTER 10: Multidrug Resistance Protein: P-Glycoprotein
CHAPTER 11: Multidrug Resistance Proteins of the ABCC Subfamily
CHAPTER 12: Breast Cancer Resistance Protein
CHAPTER 13: Drug Transport in the Liver
CHAPTER 14: Drug Transport in the Brain
CHAPTER 15: Drug Transport in the Kidney
CHAPTER 16: Drug Transporters in the Intestine
CHAPTER 17: Regulation of Drug Transporter Activity
CHAPTER 18: Experimental Approaches to the Study of Drug Transporters
CHAPTER 19: In Vitro–In Vivo Scale-up of Drug Transport Activities
CHAPTER 20: Age- and Gender-Related Differences in Xenobiotic Transporter Expression
CHAPTER 21: Polymorphisms of Drug Transporters and Clinical Relevance
CHAPTER 22: Diet/Nutrient Interactions with Drug Transporters
CHAPTER 23: Interplay of Drug Transporters and Enzymes on Hepatic Drug Processing
CHAPTER 24: Clinical Relevance: Drug–Drug Interactions, Pharmacokinetics, Pharmacodynamics, and Toxicity
Index
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Tags: Guofeng You, Marilyn E Morris, Binghe Wang, Drug Transporters, Molecular Characterization, Drug Disposition