Drug Transporters Molecular Characterization and Role in Drug Disposition 1st Edition by Guofeng You, Marilyn Morris, Binghe Wang ISBN 0471784915 9780471784913

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Product details:

ISBN 10: 0471784915

ISBN 13: 9780471784913

Author:  Guofeng You, Marilyn E. Morris, Binghe Wang 

Drug Transporters: Molecular Characterization and Role in Drug Disposition 1st Edition: 

This new edition overviews drug transporters and presents the principles of drug transport and associated techniques, featuring new chapters on multidrug and toxin extrusion proteins, placental transport,  in silico approaches in drug discovery, and regulatory guidance for drug transport studies in drug development.

• Describes drug transporter families, mechanisms, and clinical implications along with experimental methods for studying and characterizing drug transporters
• Includes new chapters on multidrug and toxin extrusion proteins, placental transport and in silico approaches in drug discovery
• Has a new chapter covering regulatory guidance for the evaluation of drug transport in drug development with global criteria used for drug transporters in clinical trials
• Arranges material to go from fundamental mechanisms to clinical outcomes, making the book useful for novice and expert readers

 

Drug Transporters: Molecular Characterization and Role in Drug Disposition 1st Edition Table of contents:

1. Overview of Drug Transporter Families
2. Organic Cation and Zwitterion Transporters (OCTs, OCTNs)
3. Organic Anion Transporters
4. Organic Anion-Transporting Polypeptides
5. Peptide Transporters
6. Monocarboxylic Acid Transporters
7. The Nucleoside Transporters CNTs and ENTs
8. Bile Salt Transporters
9. Multidrug Resistance Protein: P-Glycoprotein
10. Multidrug Resistance Proteins of the ABCC Subfamily
11. Breast Cancer Resistance Protein (BCRP) or ABCG2
12. Multidrug and Toxin Extrusion Proteins
13. Drug Transport in the Liver
14. Drug Transport in the Brain
15. Drug Transport in the Kidney
16. Drug Transporters in the Intestine
17. Drug Transport in the Placenta
18. Experimental Approaches to the Study of Drug Transporters
19. Transporters in Drug Discovery: In Silico Approaches
20. Polymorphisms of Drug Transporters and Clinical Relevance
21. Diet/Nutrient Interactions with Drug Transporters
22. Clinical Relevance: Drug–Drug Interactions, Pharmacokinetics, Pharmacodynamics, and Toxicity
23. Regulatory Science Perspectives on Transporter Studies in Drug Development

 

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Guofeng You,Marilyn Morris,Binghe Wang,Drug Transporters,Molecular,Characterization,Role,Drug Disposition