Ecology and Evolution of Cancer 1st edition by Beata Ujvari, Benjamin Roche, Frederic Thomas 0128043105 978-0128043103
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ISBN 10: 0128043105
ISBN 13: 978-0128043103
Author: Beata Ujvari, Benjamin Roche, Frederic Thomas
Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field.
The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures.
Table of contents:
Chapter 1: The Evolutionary Origins of Cancer and of Its Control by Immune Policing and Genetic Suppression
Chapter 2: Cancer Prevalence and Etiology in Wild and Captive Animals
Chapter 3: Infection and Cancer in Nature
Chapter 4: Pseudohypoxia: Life at the Edge
Chapter 5: The Genomic Landscape of Cancers
Chapter 6: The Epigenetic Component in Cancer Evolution
Chapter 7: Evolution of Cancer Defense Mechanisms Across Species
Chapter 8: Coevolution of Tumor Cells and Their Microenvironment: “Niche Construction in Cancer”
Chapter 9: Evolutionary Perspective of Tumorigenesis and Antitumor Immunity: A Comparative Approach
Chapter 10: The Response of Cancer Cell Populations to Therapies
Chapter 11: Ecology of the Metastatic Process
Chapter 12: Transmissible Cancer: The Evolution of Interindividual Metastasis
Chapter 13: Cancer in Animals: Reciprocal Feedbacks Between Evolution of Cancer Resistance and Ecosystem Functioning
Chapter 14: Applying Tools From Evolutionary Biology to Cancer Research
Chapter 15: Understanding Ancient Legacies to Expose and Exploit Cancer’s Evolutionary Vulnerabilities
Chapter 16: Atavism Theory—An Introductory Discourse
Chapter 17: Toward an Ultimate Explanation of Intratumor Heterogeneity
Chapter 18: Obstacles to the Darwinian Framework of Somatic Cancer Evolution
Chapter 19: Cancer as a Disease of Homeostasis: An Angiogenesis Perspective
Chapter 20: Dormancy: An Evolutionary Key Phenomenon in Cancer Development
Chapter 21: Controlling Rogue Cells in Cancer and Bacterial Infections
Chapter 22: Searching for a Cancer-Proof Organism: It’s the Journey That Teaches You About the Destination
Chapter 23: Ecology, Evolution, and the Cancer Patient
Index
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