Electroporation in Laboratory and Clinical Investigations 1st Edition by Enrico P Spugnini,Alfonso Baldi ISBN 161668383X 9781616683832

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Product details:

ISBN 10: 161668383X

ISBN 13: 9781616683832 

Author: Enrico P. Spugnini; Alfonso Baldi

This book provides a comprehensive overview of electroporation, a powerful technique that uses electric pulses to increase cell membrane permeability, allowing for the delivery of drugs, DNA, or other molecules into cells. It bridges the gap between laboratory research and clinical applications, making it a valuable resource for both scientists and healthcare professionals.

Key features of the book include:

• Fundamentals of Electroporation: Covers the basic principles and mechanisms of electroporation at the cellular and molecular levels, including biophysical and biochemical aspects.

• Experimental Applications: Discusses how electroporation is used in laboratory settings for gene transfer, drug delivery, and cancer therapy research.

• Clinical Case Studies: Provides detailed clinical examples of electroporation-based therapies, particularly in oncology, where it is used in electrochemotherapy for treating various tumors.

• Translational Focus: Highlights the process of translating laboratory discoveries into clinical practices, addressing safety, efficacy, and regulatory concerns.

• Innovative Therapies: Explores emerging uses of electroporation in veterinary medicine, immunotherapy, and targeted treatment delivery.

This book serves as both a scientific reference and a practical guide, making it ideal for researchers, clinicians, biomedical engineers, and students involved in cancer treatment, molecular biology, and medical device development.

Table of contents:

1. Physics and Mathematics of Electroporation

2. Technical Aspects of Electrochemotherapy

3. Non-Thermal Irreversible Electroporation for Tissue Ablation

4. Microfluidics for Electroporation

5. Mechanisms of Microorganism Inactivation by Pulsed Electric Fields

6. Electrochemical Processes Occurring During Cell Electromanipulation Procedures

7. Ultrastructural Modifications Induced by Electroporation In Vivo and In Vitro

8. Electroporation in Bacteria

9. Electroporation of Plant Cells

10. Anti-Tumoral Effects of Pulsed Low Electric Field Enhanced Chemotherapy

11. Electrogenetherapy: Electrogene Transfer Using Low Field Strength

12. Electroporation: Treating Mice or Men?

13. Electrochemotherapy in Veterinary Oncology – Part I: Solid Tumors

14. Electrochemotherapy in Veterinary Oncology – Part II: Round Cell Tumors

15. Histopathological Analysis of Canine and Feline Cancer Treated with Electrochemotherapy

16. Clinical Application of Electrochemotherapy: An Adjunct to Surgery

17. Electroporation in Chronic Lymphocytic Leukemia

18. Future Developments in Electroporation: Recombinant Clostridia as Viable and Targeted Tumour Therapeutics

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Tags: Enrico P Spugnini, Alfonso Baldi, Electroporation, Laboratory, Clinical Investigations