Endocrine Disruption and Human Health 1st Edition by Philippa D Darbre ISBN 0128011394 9780128011393
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Product details:
ISBN 10: 0128011394
ISBN 13: 9780128011393
Author: Philippa D. Darbre
Endocrine Disruption and Human Health
starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students.
Table of contents:
Section 1: Overview and Scope
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Chapter 1. What Are Endocrine Disrupters and Where Are They Found?
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Chapter 2. How Could Endocrine Disrupters Affect Human Health?
Section 2: Mechanisms and Assay Systems
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Chapter 3. Disrupters of Estrogen Action and Synthesis
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Chapter 4. Disruptors of Androgen Action and Synthesis
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Chapter 5. Disrupters of Thyroid Hormone Action and Synthesis
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Chapter 6. Disruption of Other Receptor Systems: Progesterone and Glucocorticoid Receptors, Peroxisome Proliferator-Activated Receptors, Pregnane X Receptor, and Aryl Hydrocarbon Receptor
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Chapter 7. Nonmonotonic Responses in Endocrine Disruption
Section 3: Concerns for Human Health
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Chapter 8. Endocrine Disruption and Female Reproductive Health
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Chapter 9. Endocrine Disruption and Male Reproductive Health
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Chapter 10. Endocrine Disruption and Cancer of Reproductive Tissues
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Chapter 11. Endocrine Disruption of Thyroid Function: Chemicals, Mechanisms, and Toxicopathology
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Chapter 12. Endocrine Disruption of Adrenocortical Function
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Chapter 13. Endocrine Disruption of Developmental Pathways and Children’s Health
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Chapter 14. Effects of Endocrine Disrupters on Immune Function and Inflammation
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Chapter 15. Endocrine Disruption and Disorders of Energy Metabolism
Section 4: Public Policy and Regulatory Considerations
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Chapter 16. An Introduction to the Challenges for Risk Assessment of Endocrine Disrupting Chemicals
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Chapter 17. Regulatory Considerations for Endocrine Disrupters in Food
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Chapter 18. Considerations of Endocrine Disrupters in Drinking Water
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Chapter 19. Regulatory Considerations for Dermal Application of Endocrine Disrupters in Personal Care Products
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