Enzyme Functionality Design Engineering and Screening 1st Edition by Allan Svendsen ISBN 1135525293 9781135525293

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Product details:

ISBN 10: 1135525293

ISBN 13: 9781135525293

Author:  Allan Svendsen 

Enzyme Functionality: Design: Engineering, and Screening 1st : Enzyme Functionality serves as a conduit for trailblazing research in enzyme engineering-relating current understanding of sequence families, the new notion of enzyme structure classes, and modern methods in protein engineering, design, and directed evolution to accelerate the development of novel enzyme functionalities. This reference gathers the diverse perspectives of nearly 80 scientists from around the globe and surveys all leading rational and random approaches to the artificial evolution of enzymes. Citing more than 1500 notable works, it outlines assays for enzyme activity, stability, and specificity and a wide variety of site-directed, redesign, and evolutionary engineering methods.

 

Enzyme Functionality: Design: Engineering, and Screening 1st Table of contents:

Part I: Enzyme functionality

• Chapter 1: Concepts for protein engineering
• Chapter 2: Sequence families and modular organization of carbohydrate-active enzymes
• Chapter 3: Analyzing three-dimensional structures of variant enzymes
• Chapter 4: Quantitative modeling of lipase enantioselectivity
• Chapter 5: Rational redesign of haloalkane dehalogenases guided by comparative binding energy analysis
• Chapter 6: Computer simulations: A tool for investigating the function of complex biological macromolecules
• Chapter 7: Calculations of ionization equilibria in proteins
• Chapter 8: Modeling and optimization of directed evolution protocols

Part II-A: Enzyme diversity generation – Site-directed and redesign

• Chapter 9: Rational redesign of enzymes
• Chapter 10: Details in the reaction mechanism of chitinases
• Chapter 11: Kinetic evolution to the catalytic core of the bacterial phosphotriesterase
• Chapter 12: Protein engineering of PQQ glucose dehydrogenase
• Chapter 13: The proline rule: A concept for engineering protein stability
• Chapter 14: Homing endonucleases: Tools and targets for protein engineering

Part II-B: Enzyme diversity generation – Evolutionary methods

• Chapter 15: Evolutionary methods for protein engineering
• Chapter 16: Directed evolution by random mutagenesis: A critical evaluation
• Chapter 17: Enzyme engineering by phage display
• Chapter 18: In vivo gene shuffling in yeast: A fast and easy method for directed evolution of enzymes
• Chapter 19: Effective DNA shuffling methods for enzyme evolution
• Chapter 20: Exploring the functional space of combinatorial mutant libraries for the directed evolution of novel enzyme activities
• Chapter 21: Modifying the character of an enzyme by producing chimeric enzymes: Chimeric β-glucosidases as an illustration

Part III: Screening

• Chapter 22: Assay systems for screening or selection of biocatalysts
• Chapter 23: Screening of enzyme variants for thermostability
• Chapter 24: Combinatorial mutagenesis algorithms, digital imaging spectroscopy, and solid-phase assays for directed evolution
• Chapter 25: Screen automation and robotics
• Chapter 26: Screening for enantioselective enzymes
• Chapter 27: Enzyme engineering by microbial cell surface display
• Chapter 28: Overexpression and secretion of biocatalysts in Pseudomonas
• Chapter 29: Analysis of catalytic and structural stability of native and covalently modified enzymes

 

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