Handbook of Combinatorial Chemistry Drugs Catalysts Materials 1st Edition by K C Nicolaou,Rudolf Hanko,Wolfgang Hartwig ISBN 3527305092 9783527305094

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Product details:

ISBN 10: 3527305092

ISBN 13: 9783527305094 

Author: K. C. Nicolaou, Rudolf Hanko, Wolfgang Hartwig

At long last, the mechanism-based and application-oriented handbook of combinatorial chemistry.

Since its very beginning, research in this field has continued to develop at a rapid rate. Increasingly elegant methods are being invented and an even wider range of possible applications is still being discovered, such that combinatorial chemistry is now an integral part of industrial and academic research.

The high-class editorial team – K. C. Nicolaou of The Scripps Institute and UCSD, and R. Hanko and W. Hartwig from Bayer – ensure comprehensive coverage and top quality contributions. This two-volume work deals with synthetic chemistry in all its forms, applications from life sciences, chemistry and
material sciences, all there is to know about compound library design and synthesis, and, of course, the general basics – making it an indispensable reference for synthetic, organic and medicinal chemists, chemical biologists as well as material scientists.

Table of contents:

GENERAL ASPECTS
Combinatorial Chemistry in Drug Discovery
Principles of Combinatorial Chemistry
Solid and Soluble Supports for Heterogenous Systems
Linkers for Solid Phase Synthesis
Encoding Technologies
Instrumentation for Combinatorial Chemistry

SYNTHETIC CHEMISTRY
Radical Chemistry
Nucleophilic Substitution
Electrophilic Substitution
Elimination
Addition to CC Multiple Bonds Except CC Bond Formation
Addition to CX Multiple Bonds Except CO Double Bonds
Chemistry of the Carbonyl Group
Oxidation Except CC Double Bonds
Reduction Except CC Double Bonds
Cycloaddition
Main Group Organometallics
Enolates and Related Species
Transitions Metal Catalyzed Formation of Single Bonds
Metathesis and Related Processes for CC Multiple Bond Formation

SPECIAL SYNTHETIC TOPICS
Libraries of Natural Products
Synthesis of Heterocyclic Systems
Multicomponent Reactions
Combinatorial Chemistry of Oligosaccharides

DESIGN OF COMBINATORIAL LIBRARIES
Design Criteria
Estimation of Physicochemical Parameters
Virtual Libraries and Modeling
Case Study: Medicinal Chemistry

NOVEL APPLICATIONS OF COMBINATORIAL CHEMISTRY
Combinatorial Chemistry in the Fine Chemical Industry
High Throughput Process Research
Combinatorial Approaches to Catalyst Discovery
Case Study: Combinatorial Catalyst Discovery
Combinatorial Aspects of Material Research
Combinatorial Principles of Biology and Their Potential Applications to Drug Discovery

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Tags: K C Nicolaou, Rudolf Hanko, Wolfgang Hartwig, Handbook, Combinatorial Chemistry, Drugs, Catalysts, Materials