Innovative Leukemia and Lymphoma Therapy 1st Edition by Gertjan J L Kaspers,Bertrand Coiffier,Michael C Heinrich,Elihu H Estey ISBN 0849350832 9780849350832

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Product details:

ISBN 10: 0849350832 

ISBN 13: 9780849350832

Author: Gertjan J.L. Kaspers, Bertrand Coiffier, Michael C. Heinrich, Elihu H. Estey

Innovative Leukemia and Lymphoma Therapy provides a complete and up-to-date overview of the exciting new treatment modalities in leukemia and lymphoma that are being introduced in the clinic today. Written by international experts in the field, this volume examines clinical studies on topics such as:

• tyrosine kinase inhibitors, histon deacetylase inhibitors, and farnesyl transferase inhibitors
• radioimmunotherapy, gene-directed therapy, and immunotherapy by vaccination
• monoclonal antibodies
• anti-angiogenesis approaches

Within each chapter, this well-illustrated, comprehensive source provides a summary of the rationale for treatment, the pathways that are involved, and the translational research to students, scientists, and clinicians. In addition, this book focuses on the concerns of conventional but novel anticancer agents, modulation of classical multidrug resistance, and modulators of single agent drug resistance.

Table of contents:

1. Gene Expression Profiling to Detect New Treatment Targets in Leukemia and Lymphoma: A Future Perspective

2. Individualized Tumor Response Testing in Leukemia and Lymphoma

3. Minimal Residual Disease

4. New Methods for Clinical Trials: AML as an Example

5. Monoclonal Antibody Mediated Treatment in Acute Myeloid Leukemia

6. Monoclonal Antibodies in the Treatment of Malignant Lymphomas and Chronic Lymphocytic Leukemia

7. Radioimmunotherapy of Hematological Malignancies

8. Differentiation Induction in Acute Promyelocytic Leukemia

9. DNA Methylation and Epigenetics: New Developments in Biology and Treatment

10. The Emerging Role of Histone Deacetylase Inhibitors in the Treatment of Lymphoma

11. Antileukemic Treatment Targeted at Apoptosis Regulators

12. Angiogenesis in Hematological Malignancies

13. Nucleic Acid-Based, mRNA-Targeted Therapeutics for Hematologic Malignancies

14. Active Specific Immunization by the Use of Leukemic Dendritic Cell Vaccines

15. CDK Inhibitors in Leukemia and Lymphoma

16. FLT3: A Receptor Tyrosine Kinase Target in Adult and Pediatric AML

17. Treatment of Chronic Myeloid Leukemia with Bcr-Abl Kinase Inhibitors

18. Tyrosine Kinase Inhibitors: Targets Other Than FLT3, BCR-ABL, and c-KIT

19. Tyrosine Phosphatases as New Treatment Targets in Acute Myeloid Leukemia

20. Proteasome and Protease Inhibitors

21. Farnesyltransferase Inhibitors: Current and Prospective Development for Hematologic Malignancies

22. Targeting Notch Pathways

23. mTOR Targeting Agents for the Treatment of Lymphoma and Leukemia

24. Allogeneic Hematopoietic Cell Transplantation After Nonmyeloablative Conditioning

25. Modulation of Classical Multidrug Resistance and Drug Resistance in General

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Tags: Gertjan J L Kaspers, Bertrand Coiffier, Michael C Heinrich, Elihu H Estey, Innovative, Leukemia, Lymphoma, Therapy