Joint Replacement and Bone Resorption Patholo Biomaterials and Clinical Practice 1st Edition by Arun Shanbhag, Harry E Rubash, Joshua J Jacobs ISBN 0849356210 9780849356216

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Product details:

ISBN 10: 0849356210

ISBN 13: 9780849356216 

Author: Arun Shanbhag, Harry E. Rubash, Joshua J. Jacobs

This first guide devoted to this burgeoning topic, this authoritative reference presents the current understanding of the phenomenon of aseptic loosening of total joint replacements from the molecular and cellular mechanisms of periprosthetic bone loss to the clinical presentation and management strategies-reviewing the properties of ceramic, metal, and polymer materials used in the replacement of joints, as well as current research on bone remodeling, wear resistance, the long-term care of implants, and emerging developments in gene therapy and tissue engineering.

Table of contents:

Clinical Practice

1. Historical Perspective
2. Fixation of Implants
3. THR: Incidence of Bone Loss and Clinical Presentation
4. TKR: Incidence of Bone Loss and Clinical Presentation
5. Histopathology of Periprosthetic Tissues
6. Biomaterials Wear Debris

Basic Science
7. Properties of Materials Used in Joint Replacements
8. Wear in Joint Replacements
9. Human Motion and its Relevance to Wear
10. Corrosion
11. Inflammation and the Role of Macrophages
12. Cytokines and Mediators in Physiological and Pathologic Bone Resorption
13. Mechanisms of Peri-Implant Bone Loss
14. Wear Debris Induced Osteolysis
15. Role of Immune-Response in Implant Loosening
16. Stress-Induced Bone Remodeling
17. Pressure and Motion Induced Factors in Implant Loosening
18. Role of Endotoxin in Implant Loosening
19. Signal Transduction and Gene Regulation in Cell-Material Interactions
20. In-Vitro and In-Vivo Models to Study Osteolysis

Solutions and Treatments
21. Surgical Techniques: Modern Cementing Techniques
22. Treating Hip and Pelvic Osteolysis
23. Managing Knee Osteolysis
24. Advances in Metals
25. Advances in Polyethylene
26. Improving UHMWPE Using Electron Beam Irradiation
27. Alternate Bearing Materials: Metal-on-Metal
28. Alternate Bearing Materials: Ceramic-on-Ceramic

Future Perspectives
29. Tissue Engineering Alternatives to Joint Replacement
30. Enhancing Bone Ingrowth
31. Gene Therapy for Osteolysis
32. Pharmaceutical Treatment of Lysis
33. Genomics: The Promise for Orthopaedics

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Tags: Arun Shanbhag, Harry E Rubash, Joshua J Jacobs, Joint Replacement, Bone Resorption, Pathology, Biomaterials, Clinical Practice