Lead Generation Approaches in Drug Discovery 1st Edition by Zoran Rankovic, Richard Morphy  9780470257616 047025761X

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ISBN 10: 047025761X 
ISBN 13: 9780470257616 
Author: Zoran Rankovic, Richard Morphy 

An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or “virtual” screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.

Lead Generation Approaches in Drug Discovery 1st Table of contents:

1 Lead Discovery: The Process

William F. Michne

2 High Throughput Screening Approach to Lead Discovery

Zoran Rankovic, Craig Jamieson, and Richard Morphy

3 In Silico Screening

Dagmar Stumpfe, Hanna Geppert, and Jürgen Bajorath

4 Fragment-Based Lead Discovery

Jeffrey S. Albert

5 Design of Multitarget Ligands

Richard Morphy and Zoran Rankovic

6 De novo Drug Design

Gisbert Schneider, Markus Hartenfeller, and Ewgenij Proschak

7 Role of Natural Products in Drug Discovery

Hugo Lachance, Stefan Wetzel, and Herbert Waldmann

8 Early Screening for ADMET Properties

Dennis A. Smith

9 Role of Chemistry in Lead Discovery

Roland E. Dolle and Karin Worm

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Zoran Rankovic,Richard Morphy