Life Span Extension Single Cell Organisms to Man 1st Edition by Christian Sell, Antonello Lorenzini, Holly BrownBorg ISBN 160327507X 9781603275071

Life-Span Extension: Single-Cell Organisms to Man 1st Edition by Christian Sell, Antonello Lorenzini, Holly M. Brown-Borg – Ebook PDF Instant Download/Delivery: 160327507X, 9781603275071

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Product details:

ISBN 10: 160327507X

ISBN 13: 9781603275071

Author:  Christian Sell, Antonello Lorenzini, Holly M. Brown-Borg 

Life-Span Extension: Single-Cell Organisms to Man 1st Edition: 

In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. In Life-Span Extension: Single-Cell Organisms to Man, the editors bring together a range of illuminating perspectives from researchers investigating the aging process in a variety of species. This novel work addresses the aging process in species ranging from yeast to man and, among other subjects, features detailed discussions of the naked mole-rat, an exceptionally long-lived rodent; the relationship between dietary factors/food restriction and aging; and an evolutionary view of the human aging process.

Single mutations that extend life span have been identified in yeast, worms, flies, and mice, whereas studies in humans have identified potentially important markers for successful aging. At the same time, it has been discovered that the genes and pathways identified in these studies involve a surprisingly small set of conserved functions, most of which have been the focus of aging research for some time. For example, the mTOR pathway, a regulator of translation and protein synthesis, has been identified as a common longevity pathway in yeast and Caenorhabditis elegans. In mammals, this pathway intersects with neuroendocrine pathways and with the insulin/insulin-like growth factor pathways, which have been identified as major modulators of life span and aging in both invertebrates and mice.

Novel, emerging technologies and the increasingly wide variety of systems that are now used to study aging and the mechanisms of aging provide enormous opportunities for the identification of common pathways that modulate longevity. It is these common pathways that are the focus of this important volume.

 

Life-Span Extension: Single-Cell Organisms to Man 1st Edition Table of contents:

• Yeast

  • Reprogramming cell survival and longevity: The role of Tor, Sch9, Ras, and Sir2 – Valter D. Longo (Pages 3-18)

• Caenorhabditis elegans

  • Common aging mechanisms: Energy metabolism and longevity in Caenorhabditis elegans – Marta Artal-Sanz, Nektarios Tavernarakis (Pages 21-32)
  • Conserved mechanisms of life-span regulation and extension in Caenorhabditis elegans – Sean P. Curran (Pages 33-56)

• Drosophila melanogaster

  • The genetic architecture of longevity – Robert Arking (Pages 59-73)
  • Mild stress and life extension in Drosophila melanogaster – Éric Le Bourg (Pages 75-88)

• Rodents

  • Global food restriction – Michelle E. Matzko, Roger J. McCarter, Edward J. Masoro (Pages 91-114)
  • Growth hormone and aging in mice – Holly M. Brown-Borg, Sunita Sharma, Kurt E. Borg, Sharlene G. Rakoczy (Pages 115-130)

• Comparative biology of aging

  • Exploiting natural variation in life span to evaluate mechanisms of aging – Rochelle Buffenstein (Pages 133-139)
  • Slow aging: Insights from an exceptionally long-lived rodent, the naked mole-rat – Rochelle Buffenstein, Yael H. Edrey (Pages 141-156)
  • Life extension in the short-lived fish Nothobranchius furzeri – Alessandro Cellerino (Pages 157-171)

• Aging in humans

  • Aging and longevity in animal models and humans – Miriam Capri, Stefano Salvioli, Elisa Cevenini, Laura Celani, Federica Sevini, Elena Bellavista et al. (Pages 175-191)

 

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