Molecular Machines in Biology Workshop of the Cell First Edition by Joachim Frank ISBN 0521194288 9780521194280
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ISBN 10: 0521194288
ISBN 13: 9780521194280
Author: Joachim Frank
The concept of molecular machines in biology has transformed the medical field in a profound way. Many essential processes that occur in the cell, including transcription, translation, protein folding and protein degradation, are all carried out by molecular machines. This volume focuses on important molecular machines whose architecture is known and whose functional principles have been established by tools of biophysical imaging (X-ray crystallography and cryo-electron microscopy) and fluorescence probing (single-molecule FRET). This edited volume includes contributions from prominent scientists and researchers who understand and have explored the structure and functions of these machines. This book is essential for students and professionals in the medical field who want to learn more about molecular machines.
Table of contents:
Chapter 1: Single-Molecule FRET: Technique and Applications to the Studies of Molecular Machines
Chapter 2: Visualization of Molecular Machines by Cryo-Electron Microscopy
Chapter 3: Statistical Mechanical Treatment of Molecular Machines
Chapter 4: Exploring the Functional Landscape of Biomolecular Machines via Elastic Network Normal Mode Analysis
Chapter 5: Structure, Function, and Evolution of Archaeo-Eukaryotic RNA Polymerases – Gatekeepers of the Genome
Chapter 6: Single-Molecule Fluorescence Resonance Energy Transfer Investigations of Ribosome-Catalyzed Protein Synthesis
Chapter 7: Structure and Dynamics of the Ribosome as Revealed by Cryo-Electron Microscopy
Chapter 8: Viewing the Mechanisms of Translation through the Computational Microscope
Chapter 9: The Ribosome as a Brownian Ratchet Machine
Chapter 10: The GroEL/GroES Chaperonin Machine
Chapter 11: ATP Synthase – A Paradigmatic Molecular Machine
Chapter 12: ATP-Dependent Proteases: The Cell’s Degradation Machines
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Tags: Joachim Frank, Molecular, Machines, Biology, Workshop, Cell