Neuroproteomics 1st Edition by Oscar Alzate ISBN 1420076256 9781420076257

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ISBN 10: 1420076256

ISBN 13: 9781420076257 

Author: Oscar Alzate 

In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we begin to unravel the complex mysteries of neurological diseases that less than a generation ago seemed opaque to our inquiries, if not altogether intractable.

Edited by Dr. Oscar Alzate, Neuroproteomics is the newest volume in the CRC Press Frontiers of Neuroscience Series. With an extensive background in mathematics and physics, Dr. Alzate exemplifies the newest generation of biological systems researchers. He organizes research and data contributed from all across the world to present an overview of neuroproteomics that is practical and progressive.

Bolstered by each new discovery, researchers employing multiple methods of inquiry gain a deeper understanding of the key biological problems related to brain function, brain structure, and the complexity of the nervous system. This in turn is leading to new understanding about diseases of neurological deficit such as Parkinson’s and Alzheimer’s.

Approaches discussed in the book include mass spectrometry, electrophoresis, chromatography, surface plasmon resonance, protein arrays, immunoblotting, computational proteomics, and molecular imaging. Writing about their own work, leading researchers detail the principles, approaches, and difficulties of the various techniques, demonstrating the questions that neuroproteomics can answer and those it raises.

New challenges wait, not the least of which is the identification of potential methods to regulate the structures and functions of key protein interaction networks. Ultimately, those building on the foundation presented here will advance

Table of contents:

1. Series Preface
2. Foreword
3. Preface
4. Neuroproteomics
5. Banking Tissue for Neurodegenerative Research
6. Multidimensional Techniques in Protein Separations for Neuroproteomics
7. 2-D Fluorescence Difference Gel Electrophoresis (DIGE) in Neuroproteomics
8. Mass Spectrometry for Proteomics
9. Mass Spectrometry for Post-Translational Modifications
10. MALDI Imaging and Profiling Mass Spectrometry in Neuroproteomics
11. Protein Interaction Networks
12. Knowledge-Based Analysis of Protein Interaction Networks in Neurodegenerative Diseases
13. Redox Proteomics of Oxidatively Modified Brain Proteins in Mild Cognitive Impairment
14. Neuroproteomics in the Neocortex of Mammals: Molecular Fingerprints of Cortical Plasticity
15. A Neuroproteomic Approach to Understanding Visual Cortical Development
16. Behaviorally Regulated mRNA and Protein Expression in the Songbird Brain
17. Proteomics of Experience–Dependent Plasticity in the Songbird Auditory Forebrain
18. Applications of Proteomics to Nerve Regeneration Research
19. Index

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Tags: Oscar Alzate, Neuroproteomics