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New High Throughput Technologies for DNA Sequencing and Genomics 1st Edition by Keith Mitchelson ISBN 0080471285 9780080471280

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New High Throughput Technologies for DNA Sequencing and Genomics 1st Edition Keith R. Mitchelson (Eds.) Digital Instant Download

Author(s): Keith R. Mitchelson (Eds.)
ISBN(s): 9780444522238, 0444522239
Edition: 1
File Details: PDF, 13.82 MB
Year: 2007
Language: english
SKU: EB-2164324 Category: Tag:

New High Throughput Technologies for DNA Sequencing and Genomics 1st Edition by Keith R. Mitchelson – Ebook PDF Instant Download/Delivery: 0080471285, 9780080471280

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Product details:

ISBN 10: 0080471285

ISBN 13: 9780080471280

Author:  Keith R. Mitchelson 

New High Throughput Technologies for DNA Sequencing and Genomics 1st Edition: Since the independent invention of DNA sequencing by Sanger and by Gilbert 30 years ago, it has grown from a small scale technique capable of reading several kilobase-pair of sequence per day into today’s multibillion dollar industry. This growth has spurred the development of new sequencing technologies that do not involve either electrophoresis or Sanger sequencing chemistries. Sequencing by Synthesis (SBS) involves multiple parallel micro-sequencing addition events occurring on a surface, where data from each round is detected by imaging. New High Throughput Technologies for DNA Sequencing and Genomics is the second volume in the Perspectives in Bioanalysis series, which looks at the electroanalytical chemistry of nucleic acids and proteins, development of electrochemical sensors and their application in biomedicine and in the new fields of genomics and proteomics. The authors have expertly formatted the information for a wide variety of readers, including new developments that will inspire students and young scientists to create new tools for science and medicine in the 21st century. Reviews of complementary developments in Sanger and SBS sequencing chemistries, capillary electrophoresis and microdevice integration, MS sequencing and applications set the framework for the book.

 

New High Throughput Technologies for DNA Sequencing and Genomics 1st Edition Table of contents:

Enabling Technologies

  • Overview: Developments in DNA Sequencing
  • Chip Capillary Electrophoresis and Total Genetic Analysis Systems
  • Comparative Sequence Analysis by MALDI TOF Mass Spectrometry – Utilizing the Known to Discover the New
  • Advances in Dye-Nucleotide Conjugate Chemistry for DNA Sequencing

Sequencing by Synthesis Platforms

  • The 454 Life Sciences Picoliter Sequencing System
  • An Integrated System for DNA Sequencing by Synthesis

Single Molecule Sequencing

  • Single Molecule Fluorescence Microscopy and Its Applications to Single Molecule Sequencing by Cyclic Synthesis
  • Rapid DNA Sequencing by Direct Nanoscale Reading of Nucleotide Bases on Individual DNA Chains
  • Optical Sequencing of Single DNA Molecules

Sequencing Validations and Analysis

  • Sequencing Aided by Mutagenesis (SAM) Facilitates the De Novo Sequencing of Megabase DNA Fragments by Short Read Lengths
  • Genome Sequencing and Assembly
  • Valid Recovery of Nucleic Acid Sequence Information from High Contamination Risk Samples – Ancient DNA and Environmental DNA

 

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Keith Mitchelson,New High,Throughput,Technologies,DNA,Sequencing,Genomics