OA Inflammation and Degradation A Continuum Volume 70 Biomedical and Health Research 1st Edition by J Buckwalter, M Lotz, J Stoltz ISBN 1586037730 9781586037734

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ISBN 10: 1586037730

ISBN 13: 9781586037734 

Author: J. Buckwalter, M. Lotz, J. Stoltz

Osteoarthritis is a major public health issue due to its impact in term of handicap. Moreover, ageing of the world population and outbreak of obesity in industrialized and non-industrialized countries will dramatically increase its incidence in the next years. Regarded as a multi-factorial disease, today mechanistic and inflammatory theories are no more opposed but, on the contrary, are framed within the same continuum: osteoarthritis, inflammation and degeneration. In order to collect major information in a benchmark book on the fundamental aspects of this disease, internationally well-known authors, from multiple specialties, gathered to analyze, dissect and finally try to understand the secrets of a disease which should no more be regarded as the common and relentless result of ageing or of passive wear but much more as an active disease able to benefit from the best targeted pharmacological (anti-cytokines, inhibitors of signaling pathways, inhibitors of proteases, etc.) and non-pharmacological (cellular therapy, gene therapy, cartilage engineering etc.) therapies, current and future.

Table of contents:

• Preface

• Acknowledgments and Contributors

Part I. Extra Cellular Stimuli

• I. Inflammatory Factors Involved in Osteoarthritis

• II. Mechanical Loading Effects on Articular Cartilage Matrix Metabolism and Osteoarthritis

• III. Aging, Inflammation, and Altered Chondrocyte Differentation in Articular Cartilage Calcification and Osteoarthritis

• IV. Leptin, the Prototype of Adipokines: Molecules at the Crossroads of Inflammation and Metabolism

• V. The Role of Extracellular Matrix Fragments in the Autocrine Regulation of Cartilage Metabolism

• VI. Pathophysiological Relevance of PPAR to Osteoarthritis: From the Control of Inflammation to Cartilage Protection?

Part II. Signalling Mechanisms

• VII. MAP Kinases

• VIII. Transcriptional Control of Chondrocyte Gene Expression

• IX. Gene Expression Profiling of Human Articular Chondrocytes and Osteoarthritis

Part III. Effectors and Different Pathways

• X. Prostaglandin E2 and Osteoarthritis: The Role of Cyclooxygenases, Prostaglandin E Synthases and 15-Prostaglandin Dehydrogenases

• XI. NO and Other Radicals in the Pathogenesis of Osteoarthritis

• XII. Mitochondria and Chondrocytes: Role in Osteoarthritis

• XIII. Subchondral Bone and Osteoarthritis Progression: A Very Significant Role

• XIV. Osteoarthritis and Inflammation – Inflammatory Changes in Osteoarthritic Synoviopathy

Part IV. Imaging and Clinical Applications

• XV. Magnetic Resonance Imaging of Cartilage: New Imaging and Clinical Approaches

• XVI. Multimodality of Microscopy Imaging Applied to Cartilage Tissue Engineering

• XVII. Biomarkers of Matrix Fragments, Inflammation Markers in Osteoarthritis

• XVIII. Cartilage Engineering

• XIX. Therapeutics and Osteoarthritis

• Author Index

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Tags: J Buckwalter, M Lotz, J Stoltz, OA, Inflammation, Degradation, Continuum, Biomedical, Health Research