Osteoarthritis 2nd edition by Kenneth Brandt, Michael Doherty, Stefan Lohmander ISBN 9781417599998 1417599995

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Product details: 

ISBN 10: 1417599995 

ISBN 13: 9781417599998

Author: Kenneth D. Brandt, Michael Doherty, L. Stefan Lohmander 
Scholarly document: Osteoarthritis 2nd edition Kenneth D. Brandt Instant availability. Combines theoretical knowledge and applied understanding in a well-organized educational format.

Table of contents: 

1. Definition and Classification of Osteoarthritis
2. Epidemiology of Osteoarthritis
3. The Economics of Osteoarthritis
4. Genetic Aspects of Osteoarthritis

4.1. Evidence for the Inheritance of Osteoarthritis
4.2. Specific Gene Defects Associated with Osteoarthritis
4.3. Laboratory Approaches to the Identification of Genetic Associations in Osteoarthritis

5. Pathology of Osteoarthritis
6. Paleopathology of Osteoarthritis
7. Pathogenesis of Osteoarthritis
7.1. Introduction: The Concept of Osteoarthritis as Failure of the Diarthrodial Joint
7.2. Pathogenesis of Structural Changes in the Osteoarthritic Joint
7.2.1. Articular Cartilage

7.2.1.1. Biochemistry and Metabolism of Normal and Osteoarthritic Cartilage
7.2.1.2. Proteolytic Degradation of Normal and Osteoarthritic Cartilage Matrix
7.2.1.3. Articular Cartilage Repair
7.2.1.4. Mechanical Properties of Normal and Osteoarthritic Articular Cartilage and the Mechanobiology of Chondrocytes
7.2.1.5. Response of the Chondrocyte to Mechanical Stimuli
7.2.1.6. Crystals and Osteoarthritis

7.2.2. Bone

7.2.2.1. Subchondral Bone in the Pathogenesis of Osteoarthritis: Mechanical Aspects
7.2.2.2. Subchondral Bone in the Pathogenesis of Osteoarthritis: Biological Effects
7.2.2.3. Systemic Changes in Bone in Osteoarthritis

7.2.3. Synovium

7.2.3.1. Synovial Mediators of Cartilage Damage and Repair in Osteoarthritis
7.2.3.2. Synovial Physiology in the Context of Osteoarthritis

7.2.4. Neuromuscular System

7.2.4.1. Innervation of the Joint and Its Role in Osteoarthritis
7.2.4.2. Neuromuscular Protective Mechanisms
7.2.4.3. Proprioception in Osteoarthritis

7.2.5. Local Mechanical Factors in the Natural History of Knee Osteoarthritis

Malalignment and Joint Laxity

7.3. Pathogenesis of Joint Pain in Osteoarthritis

7.3.1. Peripheral and Central Pain Mechanisms in Osteoarthritis
7.3.2. Why Does the Patient with Osteoarthritis Hurt?

8. Clinical Features of Osteoarthritis and Standard Approaches to the Diagnosis

8.1. Signs, Symptoms, and Laboratory Tests
8.2. Plain Radiographic Features of Osteoarthritis
8.3. The Natural History and Prognosis of Osteoarthritis

9. Management of Osteoarthritis

9.1. Introduction: The Comprehensive Approach
9.2. Systemic Analgesics
9.3. The Role of NSAIDs in the Treatment of Osteoarthritis
9.4. Economic Considerations in Pharmacologic Management of Osteoarthritis
9.5. Topical NSAIDs
9.6. Topical Capsaicin Cream
9.7. Intra-Articular Glucocorticoids and Other Injection Therapies
9.8. Intra-Articular Hyaluronan Injection
9.9. Nutritional Therapies
9.10. Mechanisms by Which Micronutrients May Influence Osteoarthritis

9.11. Physical Therapy

9.11.1. Exercise for the Patient with Osteoarthritis
9.11.2. Other Physical Therapies

9.12. Occupational Therapy for the Patient with Osteoarthritis
9.13. Patient Education
9.14. Social Support
9.15. Depression in Osteoarthritis
9.16. Coping Strategies for the Patient with Osteoarthritis
9.17. Irrigation of the Osteoarthritic Joint
9.18. Surgical Approaches to Preserving and Restoring Articular Cartilage
9.19. Arthroplasty and Its Complications
9.20. Weight Loss and Osteoarthritis
9.21. Patient Adherence

10. Outcome Assessment in Osteoarthritis: A Guide for Research and Clinical Practice
11. Prospects for Pharmacological Modification of Joint Breakdown in Osteoarthritis

11.1. Pharmacological Modification of Joint Breakdown in Osteoarthritis: Do We Need It, Can We Do It, Can We Prove It, Is It Good?

11.2. Disease-Modifying Osteoarthritis Drugs (DMOADs)

11.2.1. The Biological Perspective
11.2.2. The Clinical Perspective

11.3. Advantages and Limitations of Animal Models in the Discovery and Evaluation of Novel Disease-Modifying Osteoarthritis Drugs

11.4. Assessment of Changes in Joint Tissues in Patients Treated with Disease-Modifying Osteoarthritis Drugs: Monitoring Outcomes

11.4.1. Radiographic Grading Systems
11.4.2. Quantitation of Radiographic Changes
11.4.3. Magnetic Resonance Imaging
11.4.4. Arthroscopic Evaluation of Knee Articular Cartilage
11.4.5. Bone Scintigraphy
11.4.6. Ultrasonography
11.4.7. Defining and Validating the Clinical Role of Molecular Markers in Osteoarthritis

12. Design of Clinical Trials for Evaluation of Structure-Modifying Drugs and New Agents for Symptomatic Treatment of Osteoarthritis

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Tags: Kenneth Brandt, Michael Doherty, Stefan Lohmander, Osteoarthritis