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Pediatric Hematology Methods and Protocols 1st Edition by Nicholas Goulden, Colin Steward ISBN 978-1489939241 1489939245

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Pediatric Hematology Methods and Protocols 1st Edition Nicholas J. Goulden Digital Instant Download

Author(s): Nicholas J. Goulden, Colin G. Steward
ISBN(s): 9781592594337, 1592594336
Edition: 1
File Details: PDF, 4.59 MB
Year: 2003
Language: english
SKU: EB-922436 Category: Tags: ,

Pediatric Hematology Methods and Protocols 1st Edition by Nicholas J. Goulden,  Colin G. Steward- Ebook PDF Instant Download/Delivery: 978-1489939241,  1489939245
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Product details: 

ISBN 10:  1489939245

ISBN 13: 978-1489939241

Author:  Nicholas J. Goulden,  Colin G. Steward 

Much of the progress in the diagnosis, classification, and treatment of childhood hematological disorders has come from a partnership between clinicians and scientists. Indeed, access to molecular techniques is now an integral part of the practice of modern pediatric hematology. The aim of Pediatric Hematology: Methods and Protocols is to provide a collection of scientific protocols that cover the major aspects of the discipline. Most clinicians will be familiar with the difficulties inherent in establishing the underlying diagnosis in genetic marrow failure syndromes. A particular concern is failure to diagnose those associated with DNA repair defects. In Chapter 1, Dokal and colleagues present simple protocols for the molecular investigation of Fanconi anemia and dyskeratosis congenita. Molecular diagnosis is also important in children with congenital pure red cell aplasia, owing to the highly variable phenotype of this condition. In Chapter 2, Ball describes relevant protocols for the investigation of Diamond–Blackfan anemia. Hereditary hemoglobinopathy is a major cause of death and morbidity throughout the world. This area has seen great advances in screening and antenatal diagnosis. In Chapter 3, Old details protocols for the molecular diagnosis of most forms of hemoglobinopathy. High-quality, accurate molecular testing on small amounts of material has been fundamental to progress in antenatal diagnostics. The introduction to his comprehensive chapter includes a discussion of the general principles that underpin these studies. In contrast to hemoglobinopathy, severe hemophilia is uncommon.
 

Table of contents: 

  1. Bone Marrow Failure Syndromes

  2. Molecular Diagnosis of Fanconi Anemia and Dyskeratosis Congenita

  3. Molecular Diagnosis of Diamond-Blackfan Anemia

  4. Red Blood Cell Disorders

  5. Antenatal Diagnosis of Hemoglobinopathies

  6. Platelet and Hemostatic Disorders

  7. Prenatal Diagnosis of Hemophilia

  8. Human Platelet Antigen Genotyping by PCR-SSP in Neonatal/Fetal Alloimmune Thrombocytopenia

  9. Multiplex PCR for the Detection of the Factor V Leiden and Prothrombin 20210A Mutations

  10. Immunodeficiency

  11. Molecular Diagnosis of Congenital Immunodeficiency

  12. Acute Leukemia

  13. Molecular Techniques to Improve Outcome in Childhood ALL

  14. Molecular Cytogenetics in Childhood Leukemia

  15. Fluorescent IgH Fingerprinting to Assess Minimal Residual Disease in Childhood B-Lineage ALL

  16. Real-Time Quantitative RT-PCR to Detect Fusion Gene Transcripts Associated With AML

  17. Real-Time PCR to Detect Minimal Residual Disease in Childhood ALL

  18. Oligonucleotide Microarray Analysis of Gene Expression in Leukemia

  19. Bone Marrow Transplantation

  20. HLA Low-Resolution Genotyping for Hematopoietic Stem Cell Transplantation

  21. DNA Sequencing as a Tissue-Typing Tool

  22. Analysis of Chimerism After Stem Cell Transplantation

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Tags: Nicholas Goulden, Colin Steward, Pediatric Hematology, Methods and Protocols