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Phage Display In Biotechnology and Drug Discovery 2nd Edition by Ronald Geyer Clarence, Sachdev S Sidhu ISBN 1439836507 9781439836507

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Phage Display In Biotechnology and Drug Discovery 2nd Edition Clarence Digital Instant Download

Author(s): Clarence, Ronald Geyer; Sidhu, Sachdev S
ISBN(s): 9781439836507, 1439836507
Edition: 2
File Details: PDF, 60.98 MB
Year: 2015
Language: english
SKU: EB-5066802 Category: Tags: , , ,

Phage Display In Biotechnology and Drug Discovery 2nd Edition by Ronald Geyer Clarence, Sachdev S. Sidhu – Ebook PDF Instant Download/Delivery: 1439836507, 9781439836507

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Product details:

ISBN 10: 1439836507

ISBN 13: 9781439836507 

Author: Ronald Geyer Clarence, Sachdev S. Sidhu 

Phage Display in Biotechnology and Drug Discovery, Second Edition provides a comprehensive view of the impact and promise of phage display in drug discovery and biotechnology. Building on the success of its previous edition, the book discusses current theories, principles, and methods in the field and demonstrates applications for peptide phage display, protein phage display, and the development of novel antibodies.

The book provides readers with an overview of the amazing breadth of the impact that phage display technology has had on the study of proteins in general as well as the development of proteins. It will be a valuable resource for those interested in using phage display and recombinant antibodies in basic research and drug discovery.

Key Features:

  • Describes the basic principles of phage display and the methods and systems that have been developed for key applications
  • Outlines applications for peptide phage display in the development of vaccines and high- throughput screens as well as the exploration of protein–protein interactions and enzyme substrate characteristics
  • Details the use of phage display in the engineering of protein stability, the identification and mapping of protein–protein interactions, and the development of catalysts
  • Provides broad coverage of the impact of phage display technology on the development of protein therapeutics
  • Presents expert opinions on future challenges in the field

Table of contents:

  1. Filamentous Bacteriophage Structure and Biology, Diane J. Rodi, Suneeta Mandava, and Lee Makowski

  2. Vectors and Modes of Display, Valery A. Petrenko and George P. Smith

  3. Methods for the Construction of Phage-Displayed Libraries, Frederic A. Fellouse and Gabor Pal

  4. Selection and Screening Strategies, Mark S. Dennis

  5. Leveraging Synthetic Phage-Antibody Libraries for Panning on the Mammalian Cell Surface, Jelena Tomic, Megan McLaughlin, Traver Hart, Sachdev Sidhu, and Jason Moffat

  6. Phage Libraries for Developing Antibody-Targeted Diagnostics and Vaccines, Nienke E. van Houten and Jamie K. Scott

  7. Exploring Protein-Protein Interactions Using Peptide Libraries Displayed on Phage, Kurt Deshayes

  8. Substrate Phage Display, Shuichi Ohkubo

  9. Mapping Intracellular Protein Networks, Malgorzata E. Kokoszka, Zhaozhong Han, Ece Karatan, and Brian K. Kay

  10. High-Throughput and High-Content Screening Using Peptides, Robert O. Carlson, Robin Hyde-Deruyscher, and Paul T. Hamilton

  11. Engineering Protein Folding and Stability, Mihriban Tuna and Derek N. Woolfson

  12. Identification of Natural Protein-Protein Interactions with cDNA Libraries, Reto Crameri, Claudio Rhyner, Michael Weichel, Sabine Fluckiger, and Zoltan Konthur

  13. Mapping Protein Functional Epitopes, Sara K. Avrantinis and Gregory A. Weiss

  14. Selections for Enzymatic Catalysts, Julian Bertschinger, Christian Heinis, and Dario Neri

  15. Antibody Humanization and Affinity Maturation Using Phage Display, Jonathan S. Marvin and Henry B. Lowman

  16. Antibody Libraries from Immunized Repertoires, Jody D. Berry and Mikhail Popkov

  17. Naive Antibody Libraries from Natural Repertoires, Claire L. Dobson, Ralph R. Minter, and Celia P. Hart-Shorrock

  18. Synthetic Antibody Libraries, Frederic A. Fellouse and Sachdev S. Sidhu

  19. Engineering Antibody Fragments for Intracellular Applications, Jianghai Liu and C. Ronald Geyer

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Tags: Ronald Geyer, Sachdev S Sidhu, Phage Display, Biotechnology, Drug Discovery