Pharmaceutical powder compaction technology 2nd Edition by Metin Celik ISBN 0367783770 978-0367783778

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Product details: 

ISBN 10: 0367783770 

ISBN 13: 978-0367783778

Author: Metin Celik

Compaction of powder constituents―both active ingredient and excipients―is examined to ensure consistent and reproducible disintegration and dispersion profiles. Revised to reflect modern pharmaceutical compacting techniques, this second edition of Pharmaceutical Powder Compaction Technology guides pharmaceutical engineers, formulation scientists, and product development and quality assurance personnel through the compaction formulation process and application.

This unique reference covers:

The physical structure of pharmaceutical compacts

Bonding phenomena that occur during powder compaction

Compression mechanisms of pharmaceutical particles

Theories and basic principles of powder compaction

New topics include:

 

 

 

Compaction data analysis techniques

The migration of powder constituents into commercial manufacture

Instrumentation for compaction

Compaction functionality testing, which is likely to become a USP requirement

Design space for compaction

Metrics required for scalability in tablet compression

Interactive compaction and preformulation database for commonly used excipients

Table of contents: 

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1. Theory of Compaction: Intermolecular Bonding Forces: Where Materials and Process Come Together

2. Compaction Data Analysis Techniques: Viscoelastic Models

3. Application of Percolation Theory and Fractal Geometry to Tablet Compaction

4. Post Compaction Data Analysis Techniques

5. Instrumentation and Equipment in Compaction: Tablet Press Instrumentation in the Research and Development Environment

6. Advanced Compaction Research Equipment: Compaction Simulators

7. Compactability Functionality Test

8. Role of Compaction in the Formulation and Process Development of Tabletting

9. Compaction Properties of Directly Compressible Materials

10. Lubrication Issues in Direct Compaction

11. Crystal Engineering and Particle Design for the Powder Compaction Process

12. Compaction of Combination Products

13. Quality by Design and Compression

14. Expert Systems and Their Use in Pharmaceutical Applications

15. Press-To-Press Scalability and Transitioning Factors

 

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Tags: Metin Celik, Pharmaceutical powder, compaction technology