Principles and Methods of Toxicology Fifth Edition by A Wallace Hayes ISBN 084933778X 9780849337789

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ISBN 10: 084933778X

ISBN 13: 9780849337789 

Author: A. Wallace Hayes

Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential.

Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include ‘toxicopanomics’, plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology.

Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology.

Table of contents:

Part 1: Principles of Toxicology
Chapter 1. Harming and Helping through Time: The History of Toxicology (42 pages)
Chapter 2. The Use of Toxicology in the Regulatory Process (58 pages)
Chapter 3. Metabolism: A Determinant of Toxicity (76 pages)
Chapter 4. Toxicokinetics (52 pages)
Chapter 5. Physiologically Based Pharmacokinetic and Toxicokinetic Models (62 pages)
Chapter 6. Toxicopanomics: Applications of Genomics, Proteomics, and Metabonomics in Predictive and Mechanistic Toxicology (32 pages)
Chapter 7. The Toxicologic Assessment of Pharmaceutical and Biotechnology Products (44 pages)
Chapter 8. Statistics for Toxicologists (84 pages)
Chapter 9. Quantitative Extrapolations in Toxicology (22 pages)
Chapter 10. The Practice of Exposure Assessment (74 pages)
Chapter 11. Epidemiology for Toxicologists (42 pages)
Chapter 12. Principles of Pathology for Toxicology Studies (20 pages)
Chapter 13. The Information Infrastructure of Toxicology (20 pages)

Part 2: Agents
Chapter 14. Foodborne Toxicants (60 pages)
Chapter 15. Solvents and Industrial Hygiene (34 pages)
Chapter 16. Crop Protection Chemicals: Mechanisms of Action and Hazard Profiles (114 pages)
Chapter 17. Metals (56 pages)
Chapter 18. Ionizing Radiation (86 pages)
Chapter 19. Plant and Animal Toxins (70 pages)

Part 3: Methods
Chapter 20. The Use of Laboratory Animals in Toxicology Research (48 pages)
Chapter 21. Validation and Regulatory Acceptance of New, Revised, and Alternative Toxicological Methods (28 pages)
Chapter 22. Acute Toxicity and Eye Irritancy (48 pages)
Chapter 23. Genetic Toxicology (44 pages)
Chapter 24. Short-Term, Subchronic, and Chronic Toxicology Studies (42 pages)
Chapter 25. Principles of Testing for Carcinogenic Activity (52 pages)
Chapter 26. Principles of Clinical Pathology for Toxicology Studies (42 pages)
Chapter 27. Dermatotoxicology (48 pages)
Chapter 28. Inhalation Toxicology (58 pages)
Chapter 29. Detection and Evaluation of Chemically Induced Liver Injury (44 pages)
Chapter 30. Principles and Methods for Renal Toxicology (32 pages)
Chapter 31. Gastrointestinal Toxicology (44 pages)
Chapter 32. Principles and Methods of Cardiac Toxicology (20 pages)
Chapter 33. Assessment of Male Reproductive Toxicity (36 pages)
Chapter 34. Test Methods for Assessing Female Reproductive and Developmental Toxicology (72 pages)
Chapter 35. Hormone Assays and Endocrine Function (42 pages)
Chapter 36. Immunotoxicology: Effects of and Response to Drugs and Chemicals (42 pages)
Chapter 37. Assessment of Behavioral Toxicity (68 pages)
Chapter 38. Application of Isolated Organ Perfusion Techniques in Toxicology (58 pages)
Chapter 39. Organelles as Tools in Toxicology (50 pages)
Chapter 40. Analysis and Characterization of Enzymes and Nucleic Acids (68 pages)
Chapter 41. Modern Instrumental Methods for Studying Mechanisms of Toxicology (72 pages)
Chapter 42. Methods in Environmental Toxicology (42 pages)

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