Protein Trafficking in Neurons 1st Edition by Andrew Bean 9780123694379 0080465897

Protein Trafficking in Neurons 1st Edition by Andrew Bean – Ebook PDF Instant Download/Delivery: 9780123694379, 0080465897
Full download Protein Trafficking in Neurons 1st Edition after payment

Product details:

ISBN 10: 0080465897
ISBN 13: 9780123694379
Author: Andrew Bean

The efficient delivery of cellular constituents to their proper location is of fundamental importance for all cells and is of particular interest to neuroscientists, because of the unique functions and complex architecture of neurons. Protein Trafficking in Neurons examines mechanisms of protein trafficking and the role of trafficking in neuronal functioning from development to plasticity to disease. The book is divided into seven sections that review mechanisms of protein transport, the role of protein trafficking in synapse formation, exo- and endocytosis, transport of receptors, trafficking of ion channels and transporters, comparison of trafficking mechanisms in neuronal vs. non-neuronal cell types, and the relationship between trafficking and neuronal diseases such as Alzheimer’s, Huntington’s and Prion Diseases.· Provides a comprehensive examination of membrane/protein movement in neuronal function.
· Sections on synapse development, synaptic transmission, and the role of trafficking in neurological disease
· Includes a focus on Molecular Mechanisms
· Illustrated with color summary pictures
· The only book examining protein trafficking and its functional implications, written by leaders in the field

Protein Trafficking in Neurons 1st Table of contents:

SECTION I: PROTEIN MOVEMENT

CHAPTER 1: Molecular Mobility in Cells Examined with Optical Methods

I. BROWNIAN MOTION AND THE FUNDAMENTALS OF DIFFUSION

II. A VIEW OF CYTOPLASM AND MEMBRANE FROM THE SINGLE MOLECULE PERSPECTIVE

III. DIFFUSION AND MOBILITY OF PROTEINS IN CELLS STUDIED WITH BIOPHYSICAL TECHNIQUES

IV. CONCLUSIONS AND FUTURE DIRECTIONS

CHAPTER 2: The Role of Molecular Motors in Axonal Transport

I. INTRODUCTION

II. KINESIN

III. CYTOPLASMIC DYNEIN

IV. DYNACTIN

V. MYOSIN

VI. TRANSPORT REGULATION AND CONTROL

VII. AXONAL TRANSPORT

VIII. PROTEIN DEGRADATION

IX. mRNA LOCALIZATION

X. MITOCHONDRIA TRANSPORT

XI. AXON SIGNALING STRATEGY

XII. SIGNALING ADAPTORS

XIII. SURVIVAL SIGNALING

XIV. DEATH SIGNALS

XV. VIRUSES

XVI. NEURODEGENERATIVE DISEASE

XVII. SUMMARY

References

CHAPTER 3: Role of APC Complexes and the Microtubule Cytoskeleton in Neuronal Morphogenesis

I. INTRODUCTION

II. ROLE OF MICROTUBULES IN NEURONAL POLARIZATION

III. TARGETING OF APC TO TIPS OF NEURITES

IV. ROLE OF APC IN MICROTUBULE DYNAMICS AT TIPS OF NEURITES

V. SUMMARY

References

SECTION II: SYNAPTIC DEVELOPMENT

CHAPTER 4: Assembly of Synapses in the Vertebrate Central Nervous System

I. INTRODUCTION

II. CELL BIOLOGY OF CNS SYNAPSES

III. MOLECULAR MECHANISMS OF SYNAPSE FORMATION

IV. SYNAPTIC SPECIFICITY AND MOLECULAR DIVERSITY OF CELL SURFACE RECEPTORS

V. CONCLUDING REMARKS

References

CHAPTER 5: Presynaptic Terminal Differentiation

I. MORPHOLOGY OF THE PRESYNAPTIC TERMINI OF VERTEBRATE AND INVERTEBRATE SYNAPSES

II. PROTEIN COMPONENTS OF PRESYNAPTIC TERMINI

III. SNAREs

IV. FUTURE PERSPECTIVES

References

SECTION III: EXO-/ENDOCYTOSIS

CHAPTER 6: Neuronal Exocytosis

I. INTRODUCTION

II. CONCLUSIONS

References

CHAPTER 7: Endocytosis in Neurons

I. ENDOCYTOSIS IN NEURONS

II. THE CLATHRIN-DEPENDENT ENDOCYTIC MACHINERY

III. MECHANISMS OF PRESYNAPTIC VESICLE CYCLING

IV. ENDOCYTOSIS OF POSTSYNAPTIC NEUROTRANSMITTER RECEPTORS

V. CONCLUSIONS

References

SECTION IV: RECEPTOR TRAFFICKING

CHAPTER 8: Postsynaptic Machinery for Receptor Trafficking

I. POSTSYNAPTIC MICROANATOMY: DENDRITES AND SPINES

II. TRAFFICKING OF NEW RECEPTORS: DENDRITIC SECRETORY ORGANELLES

III. ENDOCYTOSIS AND THE ENDOCYTIC ZONE

IV. ENDOSOMES AND RECEPTOR RECYCLING

V. THE EXTRASYNAPTIC PLASMA MEMBRANE AND LATERAL MOVEMENT OF RECEPTORS

VI. PERSPECTIVES

References

CHAPTER 9: Synaptic Trafficking of AMPA Receptors

I. INTRODUCTION

II. REGULATED RECEPTOR ASSEMBLY AND EXIT FROM THE ER

III. DENDRITIC LOCALIZATION AND MEMBRANE INSERTION

IV. RETENTION AND CONSTITUTIVE CYCLING AT THE SYNAPSE

V. REGULATED SYNAPTIC TARGETING

VI. CONCLUSIONS

References

CHAPTER 10: Subunit-Specific NMDA Receptor Trafficking to Synapses

I. INTRODUCTION

II. ASSEMBLY OF NMDA-Rs

III. EXITING THE ENDOPLASMIC RETICULUM„THE ROLE OF NR1 SUBUNIT

IV. RELEASING THE RETENTION FROM THE ER„THE ROLE OF NR2 SUBUNITS

V. TRAFFICKING FROM THE ER TO THE PLASMA MEMBRANE

VI. TARGETING NMDA RECEPTORS TO THE SYNAPSE

VII. ACTIVITY-DEPENDENT CHANGES IN NMDA RECEPTOR SUBUNIT LOCALIZATION

VIII. TRAFFICKING REGULATION BY PHOSPHORYLATION

IX. INTERNALIZATION OF NMDA RECEPTORS

X. CONCLUSION

References

SECTION V: TRAFFICKING OF ION CHANNELS AND TRANSPORTERS

CHAPTER 11: Membrane Trafficking of Vesicular Neurotransmitter Transporters

I. INTRODUCTION

II. PLASMA MEMBRANE NEUROTRANSMITTER TRANSPORTERS

III. VESICULAR MONOAMINE AND ACETYLCHOLINE TRANSPORTERS

IV. VESICULAR GLUTAMATE TRANSPORTERS

V. CONCLUSIONS

References

CHAPTER 12: Determinants of Voltage-Gated Potassium Channel Distribution in Neurons

I. INTRODUCTION

II. MOLECULAR PROPERTIES OF Kv CHANNELS

III. DETERMINANTS OF INTRACELLULAR TRAFFICKING OF Kv CHANNELS

IV. DETERMINANTS OF POLARIZED DISTRIBUTION OF Kv CHANNELS

V. PATHOLOGICAL ALTERATIONS IN Kv CHANNEL TRAFFICKING AND DISTRIBUTION

VI. FUTURE DIRECTIONS

References

SECTION VI: TRAFFICKING IN OTHER CELL TYPES

CHAPTER 13: Protein Trafficking in the Exocytic Pathway of Polarized Epithelial Cells

I. INTRODUCTION

II. POLARIZED TRAFFICKING

III. CARGO SORTING MECHANISMS IN THE BIOSYNTHETIC ROUTES

IV. ROLE OF THE CYTOSKELETON IN POLARIZED TRAFFICKING IN EPITHELIAL CELLS

V. TETHERING, DOCKING, AND FUSION OF TRANSPORT INTERMEDIATES

VI. CONCLUDING REMARKS: NEURONAL POLARITY AND THE EPITHELIAL CELL PARADIGM

References

CHAPTER 14: Trafficking in Neuroendocrine Cells

I. INTRODUCTION

II. BIOGENESIS OF DCVs IN THE GOLGI AND THEIR MATURATION

III. CYTOPLASMIC TRANSPORT OF DCVs IS MEDIATED BY KINESIN AND MYOSIN

IV. DCVs ARE TETHERED AT THE PLASMA MEMBRANE PRIOR TO FUSION

V. WHAT MEDIATES DCV TETHERING TO THE PLASMA MEMBRANE?

VI. DOCKED DCVs REQUIRE ATP-DEPENDENT PRIMING PRIOR TO FUSION

VII. PI(4,5)P2 SYNTHESIS IS AN ESSENTIAL COMPONENT OF DCV PRIMING

VIII. WHY IS PI(4,5)P2 REQUIRED FOR DCV EXOCYTOSIS?

IX. SNARES ARE AT THE CORE OF DCV FUSION

X. SYNAPTOTAGMINS SENSE CALCIUM AND TRIGGER SNARE-DEPENDENT DCV FUSION

XI. DCV FUSION PORES DILATE OR CLOSE

XII. DYNAMIN MEDIATES PRECOCIOUS DCV FUSION PORE CLOSURE

XIII. CAVICAPTURE ALLOWS SELECTIVE RELEASE OF DCV CONSTITUENTS

References

CHAPTER 15: Exocytic Release of Glutamate from Astrocytes: Comparison to Neurons

I. INTRODUCTION

II. EXCITABILITY AND INTERCELLULAR COMMUNICATION

III. Ca-DEPENDENT EXOCYTIC RELEASE OF GLUTAMATE

IV. VESICULAR TRAFFICKING

V. INPUT AND RELEASE SITES ON ASTROCYTES

VI. CONCLUDING REMARKS

References

SECTION VII: PROTEIN TRAFFICKING AND NEURONAL DISEASE

CHAPTER 16: Trafficking Defects in Huntington’s Disease

I. GENERAL CONSIDERATIONS

II. EVIDENCE THAT htt IS A TRAFFICKING PROTEIN

III. INHIBITION OF TRAFFICKING: A PRIMARY DEFECT OR A CONSEQUENCE OF AGGREGATION?

IV. TRAFFICKING VERSUS NUCLEAR TOXICITY

V. COMMON TIES BETWEEN HD AND OTHER NEURODEGENERATIVE DISORDERS

VI. CYTOSKELETAL AND VESICULAR DYSFUNCTION

VII. MOTOR PROTEINS

VIII. THERAPEUTICS AND FUTURE DIRECTIONS

References

CHAPTER 17: Neuronal Protein Trafficking in Alzheimer’s Disease and Niemann-Pick Type C Disease

I. INTRODUCTION

II. ALZHEIMER’S DISEASE

III. NIEMANN-PICK DISEASE

IV. NPC AND AD: COMMON PATHOLOGIES

V. CONCLUSION

References

CHAPTER 18: Trafficking of the Cellular Prion Protein and Its Role in Neurodegeneration

I. INTRODUCTION

II. A BRIEF HISTORY OF PRION DISEASES

III. THE CONCEPT OF A PrP-DERIVED PROTEOME

IV. PrP BIOSYNTHESIS

V. INTRACELLULAR TRAFFICKING OF PrP

VI. PrP DEGRADATION

VII. THE IMPACT OF PrPSc ON PrPC BIOSYNTHESIS, TRAFFICKING, AND DEGRADATION

VIII. CONCLUDING REMARKS

People also search for Protein Trafficking in Neurons 1st:

protein trafficking diagram
    
protein trafficking pathways
    
protein trafficking in neurons
    
neuron trafficking
    
protein trafficking ninja nerd

Tags:

Protein Trafficking,Neurons,Andrew Bean