Protocells Bridging Nonliving and Living Matter 1st Edition by Steen Rasmussen, Mark Bedau, Liaohai Chen, David Deamer, David Krakauer, Norman Packard, Peter Stadler 9780262182683 0262182688

Protocells Bridging Nonliving and Living Matter 1st Edition by Steen Rasmussen, Mark Bedau, Liaohai Chen, David Deamer, David Krakauer, Norman Packard, Peter Stadler – Ebook PDF Instant Download/Delivery: 9780262182683, 0262182688
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ISBN 10: 0262182688
ISBN 13: 9780262182683
Author: Steen Rasmussen, Mark Bedau, Liaohai Chen, David Deamer, David Krakauer, Norman Packard, Peter Stadler

The first comprehensive general resource on state-of-the-art protocell research, describing current approaches to making new forms of life from scratch in the laboratory.

Protocells offers a comprehensive resource on current attempts to create simple forms of life from scratch in the laboratory. These minimal versions of cells, known as protocells, are entities with lifelike properties created from nonliving materials, and the book provides in-depth investigations of processes at the interface between nonliving and living matter. Chapters by experts in the field put this state-of-the-art research in the context of theory, laboratory work, and computer simulations on the components and properties of protocells. The book also provides perspectives on research in related areas and such broader societal issues as commercial applications and ethical considerations. The book covers all major scientific approaches to creating minimal life, both in the laboratory and in simulation. It emphasizes the bottom-up view of physicists, chemists, and material scientists but also includes the molecular biologists’ top-down approach and the origin-of-life perspective. The capacity to engineer living technology could have an enormous socioeconomic impact and could bring both good and ill. Protocells promises to be the essential reference for research on bottom-up assembly of life and living technology for years to come. It is written to be both resource and inspiration for scientists working in this exciting and important field and a definitive text for the interested layman.

Protocells Bridging Nonliving and Living Matter 1st Table of contents:

Front Matter

Preface

Acknowledgments

Introduction

I: Overview: Bridging Nonliving and Living Matter

1: The Early History of Protocells: The Search for the Recipe of Life

2: Experimental Approaches to Fabricating Artificial Cellular Life

3: Semisynthetic Minimal Cells: New Advancements and Perspectives

4: A Roadmap to Protocells

II: Integration

5: Steps Toward a Synthetic Protocell

6: Assembly of a Minimal Protocell

7: Population Analysis of Liposomes with Protein Synthesis and a Cascading Genetic Network

8: Constructive Approach to Protocells: Theory and Experiments

9: Origin of Life and Lattice Artificial Chemistry

10: Models of Protocell Replication

11: Compositional Lipid Protocells: Reproduction without Polynucleotides

12: Evolutionary Microfluidic Complementation Toward Artificial Cells

III: Components

13: Self-Replication and Autocatalysis

14: Replicator Dynamics in Protocells

15: Peptide Nucleic Acids as Prebiotic and Abiotic Genetic Material

16: The Core of a Minimal Gene Set: Insights from Natural Reduced Genomes

17: Parasitism and Protocells: Tragedy of the Molecular Commons

18: Forming the Essential Template for Life: The Physics of Lipid Self-Assembly

19: Numerical Methods for Protocell Simulations

20: Core Metabolism as a Self-Organized System

21: Energetics, Energy Flow, and Scaling in Life

IV: Broader Context

22: Gánti’s Chemoton Model and Life Criteria

23: Viral Individuality and Limitations of the Life Concept

24: Nonlinear Chemical Dynamics and the Origin of Life: The Inorganic-Physical Chemist Point of View

25: Early Ancestors of Existing Cells

26: Prebiotic Chemistry, the Primordial Replicator, and Modern Protocells

27: Cell-like Entities: Scientific Challenges and Future Applications

28: Social and Ethical Issues Concerning Protocells

Glossary

About the Authors

Index

Color Plates

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