Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment 1st Edition by Lutz Edler, Christos Kitsos ISBN 0470857668 9780470857663

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ISBN 10: 0470857668

ISBN 13: 9780470857663

Author:  Lutz Edler, Christos Kitsos 

Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment 1st Edition: Human health risk assessment involves the measuring of risk of exposure to disease, with a view to improving disease prevention. Mathematical, biological, statistical, and computational methods play a key role in exposure assessment, hazard assessment and identification, and dose-response modelling.

Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment is a comprehensive text that accounts for the wealth of new biological data as well as new biological, toxicological, and medical approaches adopted in risk assessment. It provides an authoritative compendium of state-of-the-art methods proposed and used, featuring contributions from eminent authors with varied experience from academia, government, and industry.

• Provides a comprehensive summary of currently available quantitative methods for risk assessment of both cancer and non-cancer problems.
• Describes the applications and the limitations of current mathematical modelling and statistical analysis methods (classical and Bayesian).
• Includes an extensive introduction and discussion to each chapter.
• Features detailed studies of risk assessments using biologically-based modelling approaches.
• Discusses the varying computational aspects of the methods proposed.
• Provides a global perspective on human health risk assessment by featuring case studies from a wide range of countries.
• Features an extensive bibliography with links to relevant background information within each chapter.

Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment will appeal to researchers and practitioners in public health & epidemiology, and postgraduate students alike. It will also be of interest to professionals working in risk assessment agencies.

 

Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment 1st Edition Table of contents:

• I: Cancer and Human Health Risk Assessment
  • 1. Principles of Cancer Risk Assessment: The Risk Assessment Paradigm
• II: Biological Aspects of Carcinogenesis
  • 2. Molecular Epidemiology in Cancer Research
  • 3. Genetic Polymorphisms in Metabolising Enzymes as Lung Cancer Risk Factors
  • 4. Biological Carcinogenesis: Theories and Models
  • 5. Biological and Mathematical Aspects of Multistage Carcinogenesis
  • 6. Risk Assessment and Chemical and Radiation Hormesis: A Short Commentary and Bibliographic Review
• III: Modeling for Cancer Risk Assessment
  • 7. Modeling Exposure and Target Organ Concentrations
  • 8. Stochastic Carcinogenesis Models
  • 9. A Unified Modeling Approach: From Exposure to Disease Endpoints
  • 10. Modeling Lung Cancer Screening
  • 11. Optimal Regimens of Cancer Screening
• IV: Statistical Approaches for Carcinogenesis Studies
  • 12. Analysis of Survival Data with Non-proportional Hazards and Crossings of Survival Functions
  • 13. Dose-response Modeling
  • 14. Benchmark Dose Approach
  • 15. Uncertainty Analysis: The Bayesian Approach
  • 16. Optimal Designs for Bioassays in Carcinogenesis
• V: Specific Modeling Approaches for Health Risk Assessment
  • 17. Cancer Risk Assessment for Mixtures
  • 18. Designs and Models for Mixtures: Assessing Cumulative Risk
  • 19. Estimating the Natural History of Breast Cancer from Bivariate Data on Age and Tumor Size at Diagnosis
• VI: Case Studies
  • 20. Statistical Issues in the Search for Biomarkers of Colorectal Cancer Using Microarray Experiments
  • 21. Optimal Experimental Designs for Prediction of Morbidity after Lung Resection
  • 22. Logistic Regression Methods and their Implementation
  • 23. The Use of Logistic Regression, Discriminant Analysis and Classification Trees in Predicting Persisting Remission in Childhood Leukemia
  • 24. Non-melanoma Skin and Lung Cancer Incidence in Relation to Arsenic Exposure: 20 Years of Observation
  • 25. Thyroid Cancer Incidence Rates in Zaragoza

 

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