Recent Progress in Alzheimer and Parkinson Diseases 1st Edition by Israel Hanin, Ramon Cacabelos, Abraham Fisher 9781841843209 1841843202

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ISBN 10: 1841843202 
ISBN 13: 9781841843209 
Author:  Israel Hanin, Ramon Cacabelos, Abraham Fisher

This book brings together the proceedings of Alzheimer’s and Parkinson’s Diseases: New Perspectives, the Sixth International Conference on Alzheimer’s Disease and Parkinson’s Disease, held recently in Seville, Spain, and discusses the latest developments in the basic science and therapy of Alzheimer’s and Parkinson’s diseases by leading specialists

Recent Progress in Alzheimer and Parkinson Diseases 1st Table of contents:

1. Mechanisms of degeneration in Parkinson’s disease

• Introduction
• Protein Aggregation: A Central Hypothesis
• Inhibitors of Aggregation
• Animal Models: Protein Aggregation in Vivo
• Parkin Accumulates in Lewy Bodies in Parkinson’s Disease Brains But Not in the A30P α-Synuclein Mouse
• Conclusion
• Acknowledgements
• References

2. Underlying biochemical and molecular mechanisms of dyskinesia

• Pathobiochemical Aspects of Dyskinesia
• Clinical Features of Dyskinesia
• Treatment of Dyskinesia
  • Treatment of Peak-Dose Dyskinesia
  • Treatment of Biphasic Dyskinesias
  • Treatment of Dystonic Dyskinesia
• Underlying Biochemical and Molecular Mechanisms of Dyskinesia
• Conclusions
• References

3. Molecular neuropathology of parkinsonism

• Introduction
• Genetics of Parkinsonism
• Molecular Classification of Parkinson’s Disease
• Synucleinopathies
• Tauopathies and the Role of Tau in Parkinson’s Disease
• Summary
• References

4. Familial parkinsonian mutations affect the ability of catecholaminergic neurons to withstand proteasome inhibition

• Introduction
• Parkinson’s Disease, Cell Loss and Lewy Pathology
• The Ubiquitin–Proteasome System and Familial Parkinsonism
• Testing the Proteasome Hypothesis
• References

5. Acetylcholinesterase, cholinergic signaling and Parkinson’s disease

• Introduction
• The Cholinergic System in Parkinson’s Disease
• Possible Genetic and Environmental Factors in Parkinson’s Disease
• Distinct Roles for Alternatively Spliced Acetylcholinesterase Variants
• Significance of Stress-Induced Shifts in Alternative Splicing
• Potential Implications for Treating Parkinson’s Disease
• Acknowledgements
• References

6. Bone marrow stem cells: possible source for cell therapy in Parkinson’s disease

• Introduction
• Bone Marrow Stromal Cells
• Multipotent Adult Progenitor Cells
• Future Strategies
• References

7. Insulin-like growth factor I and intracellular signal transduction pathways in aging and dementia

• Introduction
• IGF-I Receptor Signaling
• IGF-I Receptor Signaling and Alzheimer’s Disease
• IGF-I and Neuronal Degeneration in Alzheimer’s Disease
• IGF-I and Cerebral Amyloidosis
• IGF-I and Tau Phosphorylation
• Other Findings About IGF-I, Aging and Alzheimer’s Disease
• IGF-I-Like Mimetics in Neurodegenerative Disorders
• Conclusions
• References

8. The interrelationships between gait and cognitive function

• Introduction
• Cognitive Aspects of Normal Walking
• Why is Cognition So Important for Normal Walking?
• Gait Disturbances as a Marker of Mental Disturbances
• Mental Disturbances as Risk Factors for Gait Disturbances and Falls
• References

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