(EBOOK PDF)Stem Cells An Insider’s Guide 1st Edition by Paul Knoepfler 9789814508827 9814508829 full chapters

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• ISBN 10:9814508829 

• ISBN 13:9789814508827

• Author:Paul Knoepfler  

Stem Cells: An Insider’s Guide
Stem Cells: An Insider’s Guide is an exciting new book that takes readers inside the world of stem cells guided by international stem cell expert, Dr. Paul Knoepfler. Stem cells are catalyzing a revolution in medicine. The book also tackles the exciting and hotly debated area of stem cell treatments that are capturing the public’s imagination. In the future they may also transform how we age and reproduce. However, there are serious risks and ethical challenges, too. The author’s goal with this insider’s guide is to give readers the information needed to distinguish between the ubiquitous hype and legitimate hope found throughout the stem cell world. The book answers the most common questions that people have about stem cells. Can stem cells help my family with a serious medical problem such as Alzheimer’s, Multiple Sclerosis, or Autism? Are such treatments safe? Can stem cells make me look younger or even literally stay physically young? These questions and many more are answered here.A number of ethical issues related to stem cells that spark debates are discussed, including risky treatments, cloning and embryonic stem cells. The author breaks new ground in a number of ways such as by suggesting reforms to the FDA, providing a new theory of aging based on stem cells, and including a revolutionary Stem Cell Patient Bill of Rights. More generally, the book is your guide to where the stem cell field will be in the near future as well as a thoughtful perspective on how stem cell therapies will ultimately change your life and our world.                                                                                                                                                 

Stem Cells An Insider’s Guide 1st Table of contents:

 1 Meet Your Stem Cells
What are Stem Cells?
What Do Stem Cells Do?
A Stem Cell Fountain of Youth?
The Cancer Connection
Stem Cell Therapies
Stem Cell Veterinary Medicine: Helping Our Pets and Animals Too
Getting Schooled in Stem Cells
Recommended Stem Cell Resources
#Stemcell social media
The top stem cell journals
Patient’s guide to research papers: Be skeptical
Be aware but wary of mainstream media articles
Try to attend stem cell meetings
Summary
References
2 The Types of Stem Cells and Their Clinical Potential
What Stem Cell Treatments Promise
The Four Main Kinds of Stem Cells for Treatments
Adult stem cells
Fetal stem cells
Embryonic stem cells
Induced pluripotent stem (iPS) cells
Summary
References
3 Stem Cell Treatments: Applications and Obstacles
The Key Ways Stem Cells Can Be Used as Medicines
Cell therapy
Immunomodulation therapy
Secretion of trophic factors
Drug delivery
Powerful Applications for iPS Cells: Disease Modeling and Drug Discovery
Stem Cells May Greatly Reduce the Need for Animal Research Via Modeling
Lessons from Bone Marrow Transplants
Cautionary Lessons from Gene Therapy for the Stem Cell Field
Four Key Biological Roadblocks to Stem Cell Treatments
Immunity issues
Genome issues
Epigenome issues
Tumorigenicity
Cell Fusion and Confusion of Cell Identity
Bias
Building Rather Than Burning Stem Cell Bridges
Practical issues I: Cost
Practical issues II: Timing
What Really Happens to Transplanted Stem Cells: More Challenges
Post-transplant of stem cells, we have no control of them
Lessons from the dead: Transplanted adult stem cells generally fail to engraft
Almost certain death awaits nearly 100% of transplanted cells
Stem Cell Capsule
Summary
References
4 Stem Cell Models: Past, Present, and Future
The Discovery of Stem Cells
Models of Stem Cells Based on Function
A New Global Symbol for Stem Cells for the Future
Not Lost in Translation: A Global Model of Stem Cells for the Future
The Cultural Language of Stem Cells
References
5 All in the Family: An Insider’s Tale of Two Stem Cells and a Black Sheep
Starting the Tour: A Backstage Pass to a Stem Cell Lab
An Insider’s Tour of a Prototypic Stem Cell
The stem cell membrane
Going through the membrane into the cytoplasm
The surprisingly powerful stem cell cytoplasm
Getting to the heart of the matter: The nucleus
A Day in the Cellular Life of an Endogenous Stem Cell
The niche
Leaving the niche
My Pet Stem Cell: The Very Different Cellular Life in a Lab
Who is going to feed the stem cells and what are they going to feed them?
Who will clean up after the stem cells?
Who will take the stem cell for walks?
Where is the stem cell going to sleep?
Who will take care of the stem cell when we are on vacation?
How will you know if the stem cell is sick and what will you do about it?
What are we going to name the stem cells?
What exactly will we get out of having these stem cells?
What Could Go Wrong in the Lab?
The Black Sheep of the Family: Cancer Stem Cells
Summary
References
6 Aging: The Stem Cell Connection
Stem Cell Banking: Another Way to Battle Aging?
What types of stem cells are banked?
The cases for and against stem cell banking
Summary
References
7 Law and Order Stem Cells
US Laws and Regulations on Stem Cell Procedures
Are Stem Cells a Drug?
What are the arguments against regulating propagated stem cells as drugs?
Balancing Innovation with Safety
Compliant, but Scientifically and Medically Questionable Use of 361 Stem Cell Therapies
FDA Regulation of Stem Cell Claims
Human Subjects Research and IRBs
Stem Cell Clinical Trials Process
Suggestions for an Improved FDA of the Future
Expanding Stem Cell Compassionate Use: Proceed, but with Caution
The FDA needs more funding
Summary
References
8 Stem Cells for Profit: An Ethical Spectrum
Having Our Innovation and Ethics Too
Advanced Cell Technology
Athersys
Mesoblast
NeuralStem
The key, positive roles of investors in good citizen companies
Academic clinical researchers
The Non-Compliant, For-Profit Stem Cell World
An Overview of Ethical Landmines in Stem Cell Commercialization
Lack of Physician Training
Stem Cell Tourism
Stem Cells Go Global
Patients packing stem cells?
Call It Anything but Research: Avoiding Regulation
Potentially Divided Loyalties: Profits Versus Patients
Paying to be a human Guinea pig
Priorities: Big-money investors over patients?
Lack of Proper Informed Consent
Self-Experimentation
Recruiter-Patients
Another Clinic Trick: Fake Patients as Recruiters
Ethical Challenges in Stem Cell Social Media
Stem cell facilitators endanger patients
Recruitment of clients to other countries via social media and the internet
Stem cell sockpuppets: Intimidation as a tactic to silence clinic critics
Strategic Lawsuits Against Public Participation (SLAPP)
The Stem Cell Black Market
Non-Compliant Predictions
Increased patient lawsuits against non-compliant stem cell doctors and clinics
A Deregulated Stem Cell Future?
Summary
References
9 Patient Bill of Rights and Guide to Stem Cell Treatments
Advocacy
Attributes of successful patient advocates
Stem Cell Patient’s Bill of Rights
Article one: The right to truly informed consent
Article two: The right to receive treatment by a trained provider
Article three: The right to have your stem cells be prepared in a GMP facility
Article four: The right to continuing follow up by the provider
Article five: The right to ownership of your stem cells
Article six: The right to expanded compassionate use for fatal diseases under appropriate conditions
Article seven: The right to be in a clinical trial for experimental procedures
Article eight: The right to not be charged for clinical trial participation
Article nine: The right to full disclosure of anticipated costs
Article ten: The right to be treated regardless of socioeconomic status
An Insider’s Guide to Stem Cell Procedures
Ten things to consider before getting a stem cell procedure for yourself or a loved one
Eight simple reasons to think twice before getting an unlicensed stem cell procedure today
A reason some patients consider a high-risk stem cell treatment: The risk of doing nothing
Summary
Important Advisory
References
10 Are We There Yet? How Stem Cells Might Work to Treat Specific Diseases
Alzheimer’s Disease (AD)
Amyotrophic Lateral Sclerosis (ALS)
Arthritis
Autism
Cancer
Chronic Obstructive Pulmonary Disease (COPD)
HIV/AIDS
Huntington’s Disease
Multiple Sclerosis
Parkinson’s Disease (PD)
Spinal Cord Injury (SCI)
Summary
References
11 Stem Cell Cosmetics: More Than Skin Deep?
An Emerging Billion Dollar Industry
Stem cell creams
Medical stem cell cosmetic procedures
Recommendations from the leading plastic surgery associations on stem cell procedures
Is fat the king of stem cell cosmetics?
How are Stem Cells Isolated from Fat?
Two fat acronyms: SVF and CAL
Fat chance? Hurdles to clinical use of fat stem cells
Stem cell facelifts
Stem cell breast reconstruction and augmentation
Stem cell procedures for baldness
Summary
References
12 Stem Cell Tests for Humanity
Embryonic Stem Cells: When Does a Human Life Begin and Who Decides?
Religious authorities
Ethical authorities
Doctors
Scientists
Legal authorities
When Do Cells Become People and a Human Being’s Life Begins?
Before conception
Conception
Implantation
Heart beat as the start?
Human brain activity as the beginning?
Survival outside the womb
At birth
Overview of ideas about when a living human being begins
Emerging Ethical Debates in the Stem Cell Field
IVF: “Cure” for Infertility, But Also Gateway Technology for Questionable Practices?
IVF has created children with 3 genetic parents
Creating More Genetically Modified Humans to Potentially Treat Mitochondrial Diseases: Is It Worth the Risk?
Human Cloning and Its Technology
Somatic Cell Nuclear Transfer (SCNT)
How iPS Cell-Based Human Cloning Could Work
Phony Clone
The Ethical Complexities of Human Egg Procurement
Summary
References
13 Getting Your Stem Cell Geek On
Cool Stem Cell Ideas
Organ replacement: The stem cell human body shop?
De-extinction and extinction prevention
Stem cell-produced meat: Show me the bacon!
Zombie stem cells
Stem cells in space
Myths and Urban Legends
Myth #1: There are stem cells in Pepsi™
Myth #2: Stem cells, when eaten, are an aphrodisiac
Myth #3: Adult and autologous stem cells are by definition safe
Myth #4: iPS cells eliminate the need for embryonic stem cells
Myth #5: There is a conspiracy to kill adult stem cell therapies
Myth #6: Embryonic stem cells come from abortions
Secrets
Secret clinic-patient confidentiality clauses
Secret patient websites
The cut-throat nature of the stem cell field
Stem Cell Paradoxes
Most stem cell therapies will not transplant stem cells
Many stem cells are most similar to cancer cells
The first stem cell treatment was not known for sure to depend on stem cells
“Adult” stem cell research does not always use only adult stem cells
The main way that scientists measure pluripotency is a tumor assay
Summary
References
14 Conclusion: The Future of Stem Cells
Index

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