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Stereology for Biological Research with a Focus on Neuroscience 2nd Edition by Jack Glaser, Geoff Greene, Susan Hendricks ISBN 0978647114 9780978647117

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Stereology for Biological Research with a Focus on Neuroscience 2nd Edition Jack Glaser Digital Instant Download

Author(s): Jack Glaser, Geoff Greene, Susan Hendricks
ISBN(s): 9780978647117, 0978647114
Edition: 2nd
File Details: PDF, 7.49 MB
Year: 2007
Language: english
SKU: EB-5255750 Category: Tags: , ,

Stereology for Biological Research with a Focus on Neuroscience 2nd Edition by Jack Glaser, Geoff Greene, Susan Hendricks – Ebook PDF Instant Download/Delivery: 0978647114, 9780978647117

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Product details:

ISBN 10: 0978647114 

ISBN 13: 9780978647117

Author: Jack Glaser, Geoff Greene, Susan Hendricks 

Design-based, unbiased stereology is the standard methodology for quantitative histology because it is particularly useful for the identification of subtle yet important alterations in the morphology of the nervous system during development or disease. MBF Bioscience has been in the business of stereology for more than ten years since the creation of Stereo Investigator, the most advanced and full-featured stereology package available. MBF continues to take an active role in assisting researchers become proficient in this emerging methodology with the publication of the newly revised second edition of Stereology for Biological Research with a Focus on Neuroscience, a concise, accessible book written by MBF experts. It introduces design-based, unbiased stereology to scientists interested in, but not familiar with, the application of this methodology in neuroscience and other biomedical research fields. Covering topics such as the prerequisites for stereology research, methodology for design-based stereology, application of design-based stereology in biomedical research (such as stem cell, lung, kidney research, and Parkinson’s and Alzheimer’s diseases) as well as the future of stereology, this text is an excellent first resource for scientists.

Table of contents:

PART I How Design-Based Stereology Can Help Advance Your Research
PART II Prerequisites for Design-Based Stereological Studies

  • Can I initiate design-based stereological investigations on my existing tissue sections?

  • Is it correct that the application of design-based stereology requires the use of thick tissue sections? How thick must the sections be?

  • My tissue sections require a certain plane of section to identify the region of interest. Does this impair the applicability of design-based stereological methods?

  • Can I perform design-based stereological analyses on my existing standard laboratory microscopes, or is special equipment necessary?

  • What does computer-based stereology offer?

  • How expensive is such a semiautomated, computer-based stereology system?

PART III Design-Based Stereological Methods

  • How can I quantify the volume of my region of interest?

  • How can I quantify the total number of cells in my region of interest? How can I measure the size of the cells in my region of interest?

  • How can I determine the length density and total length of capillaries or cell processes in my region of interest?

  • How can I determine the spatial distribution of cells in my region of interest? What else can I do?

  • How can I assess the variation of estimates obtained with design-based stereology?

  • How does consideration about variability affect the implementation of design-based stereological estimators?

PART IV Application of Design-Based Stereology in Biological Research

  • Application of design-based stereology in research on brain aging and Alzheimer’s disease

  • Application of design-based stereology in schizophrenia research

  • Application of design-based stereology in stem cell research

  • Application of design-based stereology in research on the lung, kidney and placenta

PART V The Future of Design-Based Stereology

  • Development of novel design-based stereological methods

  • More precise prediction of the variability of stereological estimates

  • Integration of design-based stereology with anatomical mapping

  • Integration of design-based stereology with confocal microscopy

  • Integration of design-based stereology with digital representations of histological tissue specimens

PART VI Further Reading

  • Books dedicated to design-based stereology

  • Reviews dedicated to design-based stereology

PART VII Glossary

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Tags: Jack Glaser, Geoff Greene, Susan Hendricks, Stereology, Biological Research, Neuroscience