Strategies for Organic Drug Synthesis and Design 2nd Edition by Daniel Lednicer ISBN 0470399597 9780470399590
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ISBN 10: 0470399597
ISBN 13: 9780470399590
Author: Daniel Lednicer
Strategies for Organic Drug Synthesis and Design 2nd Edition: This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints. Written by an experienced successful author, this book meets the needs of a growing community of researchers in pharmaceutical R &D, as well as medical professionals, by providing a useful guide for designing and synthesizing pharmaceutical agents. Additionally, it is a useful text for medicinal chemistry students.
Strategies for Organic Drug Synthesis and Design 2nd Edition Table of contents:
1. PROSTAGLANDINS, PEPTIDOMIMETIC COMPOUNDS, AND RETINOIDS.
1.1 Prostaglandnis.
1.2 Peptidonimetic Compounds.
1.3 Retinoids.
1.4 A Miscellaneous Drug.
References.
2. DRUG BASED ON A SUBSTITUTED BENZENE RING
2.1 Arylethanolamines.
2.2 Aryloxypropanolamines.
2.3 Arylsulfonic Acid Derivatives.
2.4 Arylacetic and Arylpropionic Acids.
3. INDENES, NAPHTHALENES AND OTHER POLYCYCLIC AROMATIC COMPOUNDS
3.1 Indenes.
3.2 Naphthalenes.
3.3 Partly Reduced Naphthalenes.
3.4 Tricyclic Compounds.
References.
4. STEROIDS; PART 1: ESTRANES, GONANES, AND ANDROSTANES
4.1 Introduction.
4.2 Steroid Starting Materials.
4.3 Estranes.
4.4 Gonanes, the 19-nor Steroids.
4.5 Androstanes.
References.
5. STEROIDS; PART 2: COMPOUNDS RELATED TO PROGESTERONE, CORTISONE, AND CHOLESTEROL.
5.1 Introduction.
5.2 Progestins.
5.3 Corticosteroids.
5.4 Compounds Derived from Cholesterol.
References.
6. NONSTEROIDAL SEX HORMONES AND THEIR ANTAGONISTS
6.1 Introduction.
6.2 Estrogens.
References.
7. OPIOID ANAlGESICS
7.1 Introduction
7.2 Drugs Derived from Morphine.
7.3 Compounds Prepared from Thebaine.
7.4 Morphinans.
7.5 Benzomorphans.
7.6 Analgesics Based on Nonfused Piperidines.
References.
8. DRUGS BASED ON FIVE-MEMBERED HETEROCYCLES
8.1 Introduction.
8.2 Rings that Contain One Heteroatom.
8.3 Rings that Contain Two Heteroatoms.
8.4 Rings that Contains Three or More Heteroatoms.
References.
9. DRUGS BASED ON SIX-MEMBERED HETEROCYCLES.
9.1 Rings that Contain One Heteroatom.
9.2 Rings that Contain Two Heteroatoms.
9.3 Rings Containing Three Heteroatoms: The Triazines.
References.
10. FIVE-MEMBERED HETEROCYCLES FUSED TO A BENZENE RING.
10.1 Compounds that Contain One Heteroatom.
10.2 Compounds that Contain Two Heteroatoms.
10.3 Compounds that Contain Three Heteroatoms.
References.
11. SIX-MEMBERED HETEROCYCLES FUSED TO A BENZENE RING
11.1 Compounds that Contain One Heteroatom.
11.2 Compounds that Contain Two Heteroatoms.
11.3 Compounds that Contain Three Heteroatoms.
References.
12. SEVEN-MEMBERED HETEROCYCLIC FUSED TO BENZENE.
12.1 Compounds with a Single Heterocyclic Atom.
12.2 Compounds with Two Heteroatoms.
References.
13. HETEROCYLES FUSED TO TWO AROMATIC RINGS
13.1 Compounds Containing a Single Heteroatom.
13.2 Compounds Containing Two Heteroatoms.
13.3 Pyridine-Based Fused Tricyclic Compounds.
References.
14. BETA LACTAM ANTIBIOTICS
14.1 Penicillins.
14.2 Cephalosporins.
14.3 Monobactams.
References.
15. HETEROCYCLES FUSED TO OTHER HETEROCYCLIC RINGS.
15.1 Two Fused Five-Membered Rings.
15.2 Five-Membered Heterocycles Fused to Six-Membered Rings.
15.3 Two Fused Six-Membered Rings.
15.4 Heterodiazepines.
15.5 Heterocyclic Compounds with Three or More Rings.
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