The GnRH neuron and its control First Edition by Allan Herbison, Tony Plant 9781119233268 1119233267

The GnRH neuron and its control First Edition by Allan Herbison, Tony Plant  – Ebook PDF Instant Download/Delivery:9781119233268, 1119233267
Full download The GnRH neuron and its control First Edition after payment

Product details:

ISBN 10: 1119233267
ISBN 13: 9781119233268 
Author: Allan E. Herbison; Tony M. Plant

The GnRH Neuron and its Control examines the developmental biology of GnRH neurons including their birth in the nasal placode of the early embryo, perinatal programming, and sexual differentiation, in addition to the hypothalamic mechanisms that control GnRH neurons in adulthood to generate pulsatile and surge modes of GnRH secretion throughout the major life stages including aging. The morphology, electrophysiology, signal transduction pathways, transcriptional regulators, and genomics underlying function of the adult GnRH neuron is discussed in detail, as is the neuroendocrinology and cell biology governing the generation of both modes of GnRH release. The book also reviews the neurobiological mechanisms and circuitry responsible for the modulation of the activity of GnRH neurons by season, stress, nutrition, and metabolism, and covers the current and potential therapeutic approaches to regulating GnRH secretion and action. Filled with newly identified research and classical fundamental knowledge to GnRH biology, it will provide students, researchers, and practitioners with an in-depth understanding of reproductive neuroendocrinology. This is the fifth volume in the Masterclass in Neuroendocrinology Series, a co- publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.

The GnRH neuron and its control First Table of contents:

Part I: Historical Introduction to the GnRH Neuron

• Chapter 1: The Framework Upon Which Current Research on the GnRH Neuron and its Control is Built
  • Abstract
  • 1.1 Introduction
  • 1.2 Approaches taken to study the GnRH neuron
  • 1.3 The future
  • References

Part II: GnRH Neuron Development

• Chapter 2: Prenatal Development of GnRH Neurons

  • Abstract
  • 2.1 Introduction
  • 2.2 GnRH
  • 2.3 The migratory track
  • 2.4 Migration mechanics
  • 2.5 Perspectives
  • 2.6 Protocols
  • Acknowledgments
  • Glossary
  • References

• Chapter 3: Fetal/Perinatal Programming Causing Sexual Dimorphism of the Kisspeptin–GnRH Neuronal Network

  • 3.1 Discovery of perinatal programming of the GnRH/gonadotropin‐releasing system by sex steroids in rodents
  • 3.2 Critical periods responsible for sexual dimorphism of the GnRH/gonadotropin‐releasing system
  • 3.3 Sexual dimorphism of kisspeptin neurons and the GnRH‐releasing system in rodents
  • 3.4 Potential mechanisms mediating fetal/perinatal programming of the kisspeptin–GnRH neuronal network in rodents
  • 3.5 Species difference in programming of the kisspeptin–GnRH neuronal network
  • 3.6 Perspectives
  • Acknowledgments
  • References

• Chapter 4: Postnatal Development of GnRH Neuronal Function

  • Abstract
  • 4.1 Introduction
  • 4.2 Historical perspectives
  • 4.3 Postnatal development of the GnRH system
  • 4.4 The mechanism of the pubertal increase in GnRH release
  • 4.6 Perspectives
  • Acknowledgments
  • References

Part III: GnRH Neuron Biology

• Chapter 5: Regulation of GnRH Gene Expression

  • 5.1 The Gnrh1 gene and its transcript
  • 5.2 Regulation of Gnrh1 transcription
  • 5.3 Transcription factors regulating Gnrh1 transcription
  • 5.4 Gnrh1 chromatin structure is critical for increased transcription of Gnrh1 during GnRH neuron development
  • 5.5 Gnrh1 transcription regulation by noncoding RNAs
  • 5.6 Perspectives
  • Acknowledgments
  • Appendices
  • References

• Chapter 6: Morphology of the Adult GnRH Neuron

  • Abstract
  • 6.1 Introduction
  • 6.2 Immunolabeling of GnRH peptide
  • 6.3 Transgenics pave the way toward the bigger picture
  • 6.4 Putting the pieces together: visualizing the whole GnRH neuron
  • 6.5 Perspectives
  • Acknowledgments
  • Glossary
  • References

• Chapter 7: The Anatomy of the GnRH Neuron Network in the Human

  • 7.1 Ethical considerations
  • 7.2 IHC studies of developing human GnRH neurons
  • 7.3 Studying GnRH neuron anatomy in adults with ISH
  • 7.4 IHC studies of human GnRH neurons in adults
  • 7.5 Perspectives
  • Acknowledgments
  • References

• Chapter 8: Electrophysiology of Rodent GnRH Neurons

  • 8.1 Historical perspective
  • 8.2 Experimental models and recording configurations used for GnRH neuron electrophysiology
  • 8.3 Overview of the intrinsic properties of GnRH neurons
  • 8.4 Neurotransmission and neuromodulation
  • 8.5 Perspectives
  • Acknowledgment
  • References

• Chapter 9: Anatomy and Physiology of GnRH Neurons and Their Control of Pituitary Function in Fish

  • Abstract
  • 9.1 Introduction
  • 9.2 Anatomy and ontogeny of GnRH neurons, with special reference to the hypophysiotropic GnRH1 neurons
  • 9.3 Electrophysiology of hypophysiotropic GnRH1 neurons in fish
  • 9.4 Physiological functions of teleost GnRH1 neurons: implications from gene KO animals
  • 9.5 Perspectives
  • Acknowledgments
  • References

Part IV: Regulation of GnRH Neuron Function

• Chapter 10: Unveiling the Importance of Glia and Vascular Endothelial Cells in the Control of GnRH Neuronal Function

  • 10.1 Defining the functional microunit in the GnRH neuroendocrine network
  • 10.2 Visualizing morphological interactions between GnRH neurons and glial cells
  • 10.3 Evidence for gliotransmission in the GnRH neural network
  • 10.4 Probing function‐related structural plasticity in the GnRH neural network
  • 10.5 Deciphering the cell‐to‐cell communication processes underlying structural plasticity
  • 10.6 Perspectives
  • Acknowledgments
  • Glossary
  • References

• Chapter 11: Genetic Strategies Examining Kisspeptin Regulation of GnRH Neurons

  • Abstract
  • 11.1 Introduction
  • 11.2 The ARC kisspeptin neuron population
  • 11.3 The AVPV/PeN kisspeptin neurons
  • 11.4 Steroidogenic control of GnRH neurons via kisspeptin neurons
  • 11.5 Interrogation of kisspeptin neurobiology
  • 11.6 How comparable is the rodent to the human?
  • 11.7 Perspectives
  • Acknowledgments
  • Glossary
  • References

• Chapter 12: KNDy Hypothesis for Generation of GnRH Pulses: Evidence from Sheep and Goats

  • 12.1 Introduction
  • 12.2 Anatomical approaches
  • 12.3 Functional approaches: local administration of receptor agonists and antagonists and assessment of MUA
  • 12.4 Integration: the KNDy hypothesis in ruminants and rodents
  • 12.5 Perspectives
  • Acknowledgments
  • Appendices
  • References

Part V: GnRH in the Clinic

• Chapter 17: Human Genetics of GnRH Neuron Function

  • Abstract
  • 17.1 Introduction
  • 17.2 Human phenotypes of early and late pubertal development
  • 17.2.2.1 GNRHR and GNRH1
  • 17.2.2.2 KISS1R and KISS1
  • 17.3 KNDy neurons as the GnRH pulse generator
  • 17.4 Genome‐wide association studies on the age of menarche
  • 17.5 Finding new puberty genes
  • 17.6 Challenges in finding new puberty genes
  • 17.7 Perspectives
  • Glossary
  • Acknowledgment
  • References

• Chapter 18: Modulators of GnRH Secretion and Therapeutic Applications

  • Abstract
  • 18.1 Introduction
  • 18.2 GnRH analogs
  • 18.3 Kisspeptin analogs
  • 18.4 NKB analogs
  • 18.5 Perspectives
  • Acknowledgments
  • Glossary
  • References

People also search for The GnRH neuron and its control First:

    
the hypothalamic neurons that synthesize gnrh have receptors for estrogen
    
gnrh is secreted by the anterior pituitary
    
gnrh from the hypothalamus stimulates the anterior pituitary to produce
    
the release of gnrh before puberty is
    
gnrh is secreted by the

Tags:

Allan Herbison,Tony Plant,neuron