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The Role of Microtubules in Cell Biology Neurobiology and Oncology Cancer Drug Discovery and Development 1st Edition by Antonio Tito Fojo ISBN 1588292940 978-1588292940

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The Role of Microtubules in Cell Biology Neurobiology and Oncology Cancer Drug Discovery and Development 1st Edition Antonio Tito Fojo Digital Instant Download

Author(s): Antonio Tito Fojo
ISBN(s): 9781588292940, 1588292940
Edition: 1
File Details: PDF, 10.87 MB
Year: 2008
Language: english
SKU: EB-1749762 Category: Tag:

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Product details:

ISBN 10: 1588292940

ISBN 13: 978-1588292940 

Author: Antonio Tito Fojo

I want to thank all who contributed to this first edition for their hard work and professionalism, and especially for their patience. I hope the readers will find this volume as helpful as I have found it. There is no doubt that the family of proteins we call the tubulins and the microtubules that they form when they aggregate are extremely important in the cell and, as we are increasingly learning, important in diseases that afflict so many. This field of investi- tion is a testament to how important both basic and clinical sciences are in understanding disease mechanisms and making inroads into therapies. Without the basic science knowledge that has been accumulated, to which the authors of this work have contributed greatly, we would not be in the position we find ourselves of increasingly understanding disease and advancing therapies. As I read the chapters, I was humbled to think of the insights that so many have contributed to this field, and again became aware of how the collaborative effort of so many is needed to understand the complexities of nature. By working together, many have helped to advance this field. Because of their efforts, we find ourselves with the wealth of knowledge contained in this book. This knowledge gives us so much insight even as it challenges us to continue working. Thanks again to all of the wonderful collaborators for their excellence and their patience. 

Table of contents:

  1. An Overview of Compounds That Interact with Tubulin

  2. Molecular Mechanisms of Microtubule Acting

  3. Mechanisms and Regulation

  4. Microtubule Associated Proteins

  5. The Post-Translational Modifications of Tubulin

  6. Distribution

  7. The Tubulin Superfamily

  8. Tubulin Proteomics in Cancer

  9. Tubulin and Microtubule Structures

  10. Peptides and Depsipeptides

  11. Molecular Features of the Interaction of Colchicine

  12. Microtubule Stabilizing Agents

  13. Mechanisms of Resistance to Drugs That Interfere

  14. Resistance to Microtubule-Targeting Drugs

  15. Microtubule Stabilizing Agents in Clinical

  16. Investigational Anticancer Agents Targeting

  17. Microtubule Damaging Agents and Apoptosis

  18. Microtubule Targeting Agents and the Tumor Vasculature

  19. Tau Proteins in Neurodegenerative

  20. Structure, Function and Regulation of the Microtubule

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Tags: Antonio Tito Fojo, Role, Microtubules, Cell Biology, Neurobiology, Oncology, Cancer, Drug Discovery, Development