Toxicology of the Kidney Target Organ Toxicology Series 3rd Edition by Joan B Tarloff, Lawrence H Lash ISBN 0415248647 9780415248648

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Product details:

ISBN 10: 0415248647 

ISBN 13: 9780415248648

Author: Joan B. Tarloff, Lawrence H. Lash

The kidney plays a vital role in certain endocrine functions. Abnormalities caused by toxic chemicals or other interventions can have profound effects on these functions and consequently, on total functions. Toxicology of the Kidney, Third Edition is updated to reflect the latest research in this field and focuses on the correlation between anatomy, biochemistry, and physiology of the kidney. The text explains how these factors are related to concepts of clinical nephrotoxicity and renal failure in humans, and how animal models can be used to understand the mechanisms of human renal disease. In addition to updating many of the key elements of previous editions, such as in vitro models for studying renal function and toxicity and classic nephrotoxicants, it also incorporates cutting edge information on newly emerging areas of renal research. These include mechanisms of cell injury, signaling pathways, biomarkers of renal disease and the interface between basic renal science and clinical outcomes. This book includes current reviews of unpublished and recently published information which allows it to serve as a concise compendium of many key topics that will continue to play a central role in our understanding and treatment of nephrotoxicity for decades to come.

Table of contents:

Part I: Basic Principles
1. Anatomy and Physiology of the Kidneys
2. Molecular and Cell Biology of Normal and Diseased or Intoxicated Kidney
3. Assessing Renal Effects of Toxicants In Vivo
4. In vitro Techniques in Screening and Mechanistic Studies: Organ Perfusion, Slices, and Nephron Co
5. In Vitro Techniques in Screening and Mechanistic Studies: Cell Culture, Cell-Free Systems, and Mo
Part II: Mechanisms of Nephrotoxicity
6. Role of Xenobiotic Metabolism
7. Mechanisms of Renal Cell Death
8. Signal Transduction in Renal Cell Repair and Regeneration
9. Chemical-Induced Nephrocarcinogenicity in the Eker Rat: A Model of Chemical-Induced Renal Carcino
10. The Role of Endocytosis in Nephrotoxicity
11. Role of Cellular Energetics in Nephrotoxicity
12. Adhesion Molecules in Renal Physiology and Pathology
13. Oxidant Mechanisms in Toxic Acute Renal Failure
Part III: Clinical Nephrotoxicity and Specific Classes of Nephrotoxicants
14. Vasoactive and Inflammatory Substances
15. Analgesic Nephropathy
16. Antibiotic-Induced Nephrotoxicity
17. Nephrotoxicity of Cyclosporine and Other Immunosuppressive and Immunotherapeutic Agents
18. Cisplatin-Induced Nephrotoxicity
19. The Pathogenesis and Prevention of Radiocontrast Medium Induced Renal Dysfunction
20. Analgesics and Nonsteroidal Anti-Inflammatory Drugs
21. Mycotoxins Affecting the Kidney
22. Nephrotoxicology of Metals
23. Chemical-Induced Nephrotoxicity Mediated by Glutathione S-Conjugate Formation
Part IV: Risk and Safety Assessment
24. The Role of Epidemiology in Human Nephrotoxicity
25. Age, Sex and Species Differences in Nephrotoxic Response
26. Risk Assessment of Nephrotoxic Metals
27. Risk Assessment for Selected Therapeutics
Index

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Tags: Joan B Tarloff, Lawrence H Lash, Toxicology, Kidney, Target Organ, Toxicology Series