Viral Therapy of Cancer 1st Edition by K J Harrington ISBN 0470019220 9780470019221

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ISBN 10: 0470019220 

ISBN 13: 9780470019221

Author: K. J. Harrington

In the last decade there has been an explosion of interest in viral therapies for cancer. Viral agents have been developed that are harmless to normal tissues but selectively able to kill cancer cells. These agents have been endowed with additional selectivity and potency through genetic manipulation. Increasingly these viruses are undergoing evaluation in clinical trials, both as single agents and in combination with standard chemotherapy and radiotherapy. 

This book provides a comprehensive yet succinct overview of the current status of viral therapy of cancer. Chapters coherently present the advances made with individual agents and review the biological and clinical background to a range of viral therapies: structured to proceed from basic science at the bench to the patient’s bedside, they give an up-to-date and realistic evaluation of a therapy’s potential utility for the cancer patient.

• Presents state of the art knowledge on how viruses can be, and have been, used in novel therapeutic approaches for the treatment of cancer
• Describes the use of viruses as oncolytic agents, killing cells directly
• Editors are experts in the field, with experience of both laboratory and clinical research

Viral Therapy of Cancer is essential reading for both basic scientists and clinicians with an interest in viral therapy and gene therapy.

Table of contents:

Chapter 1 Adenoviruses
Chapter 2 Application of HSV-1 Vectors to the Treatment of Cancer
Chapter 3 Adeno-Associated Virus
Chapter 4 Retroviruses
Chapter 5 Lentiviral Vectors for Cancer Gene Therapy
Chapter 6 Poxviruses as Immunomodulatory Cancer Therapeutics
Chapter 7 Oncolytic Herpes Simplex Viruses
Chapter 8 Selective Tumour Cell Cytotoxicity by Reoviridae – Preclinical Evidence and Clinical Trial Results
Chapter 9 Oncolytic Vaccinia
Chapter 10 Newcastle Disease Virus: A Promising Vector for Viral Therapy of Cancer
Chapter 11 Vesicular Stomatitis Virus
Chapter 12 Measles as an Oncolytic Virus
Chapter 13 Alphaviruses
Chapter 14 Tumour-Suppressor Gene Therapy
Chapter 15 RNA Interference and Dominant Negative Approaches
Chapter 16 Gene-Directed Enzyme Prodrug Therapy
Chapter 17 Immunomodulatory Gene Therapy
Chapter 18 Antiangiogenic Gene Delivery
Chapter 19 Radiosensitization in Viral Gene Therapy
Chapter 20 Radioisotope Delivery
Chapter 21 Radioprotective Gene Therapy: Current Status and Future Goals
Chapter 22 Chemoprotective Gene Delivery

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Tags: K J Harrington, Viral Therapy, Cancer